ArticleBiophysical journal2008
Interleaflet coupling mechanisms in bilayers of lipids and cholesterol.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Quantifying interleaflet coupling of phase behavior and observing anti-registered phases in asymmetric lipid bilayers.Biophysical journal · 2026Article
- Quantifying interleaflet coupling of phase behavior and observing anti-registered phases in asymmetric lipid bilayers.bioRxiv : the preprint server for biology · 2026Article
- A model for membrane curvature generation by caveolin discs driven by differential contact interaction.Nature communications · 2025Article
- The Importance of Bilayer Asymmetry in Biological Membranes: Insights from Model Membranes.Membranes · 2025Review
- Measuring the Transmembrane Registration of Lipid Domains in Droplet Interface Bilayers through Tensiometry.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Experimentally determined leaflet-leaflet phase diagram of an asymmetric lipid bilayer.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cholesterol, Eukaryotic Lipid Domains, and an Evolutionary Perspective of Transmembrane Signaling.Cold Spring Harbor perspectives in biology · 2023Review
- Structure and Interdigitation of Chain-Asymmetric Phosphatidylcholines and Milk Sphingomyelin in the Fluid Phase.Symmetry · 2021Article
- Investigation of the domain line tension in asymmetric vesicles prepared via hemifusion.Biochimica et biophysica acta. Biomembranes · 2021Article
- Interleaflet Coupling of Lipid Nanodomains - Insights FromFrontiers in cell and developmental biology · 2020Review
- HIV-1 Gag specifically restricts PI(4,5)P2 and cholesterol mobility in living cells creating a nanodomain platform for virus assembly.Science advances · 2019Article
- Role of Transmembrane Proteins for Phase Separation and Domain Registration in Asymmetric Lipid Bilayers.Biomolecules · 2019Article
- Understanding Conformational Dynamics of Complex Lipid Mixtures Relevant to Biology.The Journal of membrane biology · 2018Review
- Effects of Passive Phospholipid Flip-Flop and Asymmetric External Fields on Bilayer Phase Equilibria.Biophysical journal · 2018Article
- Cholesterol Flip-Flop Impacts Domain Registration in Plasma Membrane Models.The journal of physical chemistry letters · 2018Article
- Intrinsic Curvature-Mediated Transbilayer Coupling in Asymmetric Lipid Vesicles.Biophysical journal · 2018Article
- Lipid Domain Co-localization Induced by Membrane Undulations.Biophysical journal · 2017Article
- The aliphatic chain of cholesterol modulates bilayer interleaflet coupling and domain registration.FEBS letters · 2016Article
- Continuity of Monolayer-Bilayer Junctions for Localization of Lipid Raft Microdomains in Model Membranes.Scientific reports · 2016Article
- Relaxation dynamics of two-component fluid bilayer membranes.The European physical journal. E, Soft matter · 2016Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whereas it appears to be generally believed that the leaflets of a phospholipid/cholesterol bilayer interact with each other in some way, the exact mechanism remains undetermined. Various suggestions have been invoked, including chain interdigitation and rapid translocation of cholesterol. There is little, if any, direct evidence supporting or excluding these hypotheses. In this letter, I examine a few different possibilities. Chain interdigitation is unlikely to be significant. Cholesterol translocation meets some, though not all, of the relevant criteria, and probably plays an important role. The simplest explanation is that the layers interact at the midplane in the same way that the ordered and disordered liquid phases common in these systems interact at their interfaces. A quick estimate of that interfacial energy shows that this is a very likely candidate. The consequences of such an energy in biological systems are briefly considered.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.