ArticleNucleic acids research2008
Role of poly (A) tail as an identity element for mRNA nuclear export.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed.
- Analysis ofMicroorganisms · 2026Article
- Extended poly(A) tails are a shared feature of herpesvirus mRNAs.PLoS pathogens · 2026Article
- Characterising the Transcriptomic Response to Interferon and Infection in European Domestic Ferret Respiratory Tissues Using Long-Read RNA Sequencing.Immunology · 2026Article
- Extended poly(A) tails are a shared feature of herpesvirus mRNAs.bioRxiv : the preprint server for biology · 2025Article
- Poly(A) tail regulation in stem cells and early development.Cell regeneration (London, England) · 2025Review
- Strict retroelement regulation is frequently lost following cancer transformation and generates a promising reservoir of cancer biomarkers.Mobile DNA · 2025Article
- Identification of post-transcriptional regulation reveals complexity in peanut pod development by Direct RNA.aBIOTECH · 2025Article
- Multiome Perturb-seq unlocks scalable discovery of integrated perturbation effects on the transcriptome and epigenome.Cell systems · 2025Article
- Using synthetic RNA to benchmark poly(A) length inference from direct RNA sequencing.GigaScience · 2025Article
- A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs.PLoS genetics · 2025Article
- Advances in Nonviral mRNA Delivery Materials and Their Application as Vaccines for Melanoma Therapy.ACS applied bio materials · 2024Review
- Multiome Perturb-seq unlocks scalable discovery of integrated perturbation effects on the transcriptome and epigenome.bioRxiv : the preprint server for biology · 2024Article
- A transposable element prevents severe hemophilia B and provides insights into the evolution of new- and old world primates.PloS one · 2024Article
- The polyA tail facilitates splicing of last introns with weak 3' splice sites via PABPN1.EMBO reports · 2023Article
- RNA modification in mRNA cancer vaccines.Clinical and experimental medicine · 2023Review
- mRNA vaccines in disease prevention and treatment.Signal transduction and targeted therapy · 2023Review
- The hnRNP C tetramer binds to CBC on mRNA and impedes PHAX recruitment for the classification of RNA polymerase II transcripts.Nucleic acids research · 2023Article
- Comprehensive profiling of epigenetic modifications in fast-growing Moso bamboo shoots.Plant physiology · 2023Article
- Article
- Measuring the tail: Methods for poly(A) tail profiling.Wiley interdisciplinary reviews. RNA · 2023Review
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Different RNA species are rigorously discriminated and exported by distinct export factors, but this discrimination mechanism remains largely unknown. We previously showed, by RNA microinjection experiments, that intronless mRNAs are discriminated from U snRNAs based on their difference in RNA length. However, it was unclear how they are discriminated in the natural situation in which their nascent transcripts emerge progressively during transcription. We hypothesized that transcription from the corresponding promoters is important for this discrimination. Here we show that contrary to our hypothesis, the discrimination process was not significantly influenced by whether transcription occurred from an mRNA- versus a U snRNA-type promoter. Rather, the features of transcribed RNAs determined the RNA identity, consistent with our previous results of RNA microinjection. Moreover, we found that the poly (A) tail can function as an identity element for mRNA export. The presence of a poly (A) tail of an appropriate length committed otherwise short Pol II transcripts to the mRNA export pathway in a dominant manner, indicating that the poly (A) tail either contributes to increasing the RNA length or functions as a platform to recruit mRNA export factors. Our results reveal a novel function of the poly (A) tail in mRNA export.
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