ArticleThe Journal of physiology2008
Serotonin differentially modulates the intrinsic properties of spinal motoneurons from the adult turtle.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- 5-HTThe Journal of physiology · 2025Trial
- Enhanced availability of serotonin increases activation of unfatigued muscle but exacerbates central fatigue during prolonged sustained contractions.The Journal of physiology · 2019Trial
- Ionic Mechanisms Underlying Bistability in Spinal Motoneurons: Insights from a Computational Model.bioRxiv : the preprint server for biology · 2025Article
- Ionic mechanisms underlying bistability in spinal motoneurons: insights from a computational model.Frontiers in cellular neuroscience · 2025Article
- Altered flexor carpi radialis motor axon excitability properties after cerebrovascular stroke.Frontiers in neurology · 2023Article
- Voluntary activation of muscle in humans: does serotonergic neuromodulation matter?The Journal of physiology · 2022Review
- Review
- The serotonin reuptake blocker citalopram destabilizes fictive locomotor activity in salamander axial circuits through 5-HTJournal of neurophysiology · 2020Article
- Respiratory motoneuron properties during the transition from gill to lung breathing in the American bullfrog.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Constitutive activity of 5-HTJournal of neurophysiology · 2017Article
- Spike threshold dynamics in spinal motoneurons during scratching and swimming.The Journal of physiology · 2017Article
- Intense Activity of the Raphe Spinal Pathway Depresses Motor Activity via a Serotonin Dependent Mechanism.Frontiers in neural circuits · 2017Article
- Unexpected factors affecting the excitability of human motoneurones in voluntary and stimulated contractions.The Journal of physiology · 2016Article
- Serotonergic regulation of excitability of principal cells of the dorsal cochlear nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Exploring the central modulation hypothesis: do ancient memory mechanisms underlie the pathophysiology of trigger points?Current pain and headache reports · 2013Review
- Constitutively active 5-HT2/α1 receptors facilitate muscle spasms after human spinal cord injury.Journal of neurophysiology · 2013Article
- Extrasynaptic neurotransmission as a way of modulating neuronal functions.Frontiers in physiology · 2012Article
- Evaluation of the analgesic effects of oral and subcutaneous tramadol administration in red-eared slider turtles.Journal of the American Veterinary Medical Association · 2011Article
- Motoneuron excitability: the importance of neuromodulatory inputs.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2009Review
- The cortex, interneurones and motoneurones in the control of movement.The Journal of physiology · 2008Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This report considers serotonergic (5-HT) effects on spinal motoneurons, reviewing previous data and presenting a new study showing distinct effects of two 5-HT receptor subtypes. We previously investigated the effects of 5-HT on motoneurons in a slice preparation from the spinal cord of the adult turtle. In agreement with previous studies, we had found that 5-HT applied to the extracellular medium promoted a voltage sensitive plateau potential. However, we also reported that this effect was only observed in half of the motoneurons; 5-HT inhibited the firing of the other half of the motoneurons recorded from. To investigate the reasons for this, we applied 5-HT focally by means of the microiontophoresis technique. Facilitation of plateau potentials was observed when 5-HT was released at sites throughout the somatodendritic region. However, motoneurons were inhibited by 5-HT when selectively applied in the perisomatic region. These two effects could be induced in the same motoneuron. With pharmacological tools, we demonstrate here that the facilitation of plateau potentials is mediated by 5-HT(2) receptors and the inhibitory effect is due to the activation of 5-HT(1A/7) receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.