ArticleThe Journal of physiology2008
Flow-mediated dilatation in the superficial femoral artery is nitric oxide mediated in humans.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 2 of them syntheses that pooled it.
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Who cites it
89 citing papers in PubMed, 2 syntheses or guidelines pooled it, 205 citations in OpenAlex.
- Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test.Journal of visualized experiments : JoVE · 2016Guideline
- Assessment of flow-mediated dilation in humans: a methodological and physiological guideline.American journal of physiology. Heart and circulatory physiology · 2011 · on this mapGuideline
- Dietary flavanols preserve upper- and lower-limb endothelial function during sitting in high- and low-fit young healthy males.The Journal of physiology · 2026Trial
- Cold pressor-induced sympathetic activation blunts the femoral but not carotid artery vascular responsiveness.Physiological reports · 2025Trial
- The effect of four weeks blood flow restricted resistance training on macro- and micro-vascular function in healthy, young men.European journal of applied physiology · 2023Trial
- Trial
- Impact of pulsed electromagnetic field therapy on vascular function and blood pressure in hypertensive individuals.Journal of clinical hypertension (Greenwich, Conn.) · 2020Trial
- Reducing Dietary Sodium to 1000 mg per Day Reduces Neurovascular Transduction Without Stimulating Sympathetic Outflow.Hypertension (Dallas, Tex. : 1979) · 2019Trial
- Effects of prior aerobic exercise on sitting-induced vascular dysfunction in healthy men.European journal of applied physiology · 2017Trial
- Antioxidant vitamin C prevents decline in endothelial function during sitting.Medical science monitor : international medical journal of experimental and clinical research · 2015Trial
- The effects of acute garlic supplementation on the fibrinolytic and vasoreactive response to exercise.Journal of the International Society of Sports Nutrition · 2015Trial
- The effect of acute exercise in hypoxia on flow-mediated vasodilation.European journal of applied physiology · 2013Trial
- Whole-body vibration attenuates the increase in leg arterial stiffness and aortic systolic blood pressure during post-exercise muscle ischemia.European journal of applied physiology · 2011Trial
- The effect of oral antioxidants on brachial artery flow-mediated dilation following 5 and 10 min of ischemia.European journal of applied physiology · 2009Trial
- Effects of acute nitric oxide synthase inhibition on lower leg vascular function in chronic tetraplegia.The journal of spinal cord medicine · 2009Trial
- The impact of a 12-week high-intensity interval training program on popliteal vascular responses to prolonged sitting.European journal of applied physiology · 2026Article
- Effect of breaking up sitting with regular active breaks on glucose management and vascular function in adults with type 1 diabetes who use hybrid closed-loop insulin delivery systems: a randomised crossover trial protocol.BMJ open sport & exercise medicine · 2026Article
- Leg vascular function with advancing age in men: the impact of physical activity and endurance exercise training.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- African Americans with a family history of cardiovascular disease show lower endothelial-dependent vasodilation.Physiological reports · 2025Article
- Reliability of popliteal artery flow-mediated dilation in the seated position.Physiological reports · 2025Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flow-mediated dilatation (FMD) of the brachial and radial arteries is an important research tool for assessment of endothelial function in vivo, and is nitric oxide (NO) dependent. The leg skeletal muscle vascular bed is an important territory for studies in exercise physiology. However, the role of endothelial NO in the FMD response of lower limb arteries has never been investigated. The purpose of this study was to examine the contribution of NO to FMD in the superficial femoral artery in healthy subjects. Since physical inactivity may affect endothelial function, and therefore NO availability, spinal cord-injured (SCI) individuals were included as a model of extreme deconditioning. In eight healthy men (34 +/- 13 years) and six SCI individuals (37 +/- 10 years), the 5 min FMD response in the superficial femoral artery was assessed by echo-Doppler, both during infusion of saline and during infusion of the NO synthase blocker N(G)-monomethyl-L-arginine (L-NMMA). In a subset of the controls (n = 6), the 10 min FMD response was also examined using the same procedure. The 5 min FMD response in controls (4.2 +/- 0.3%) was significantly diminished during L-NMMA infusion (1.0 +/- 0.2%, P < 0.001). In SCI, L-NMMA also significantly decreased the FMD response (from 8.2 +/- 0.4% during saline to 2.4 +/- 0.5% during L-NMMA infusion). The hyperaemic flow response during the first 45 s after cuff deflation was lower in both groups during infusion of L-NMMA, but the effect of L-NMMA on FMD persisted in both groups after correction for the shear stress stimulus. The 10 min FMD was not affected by L-NMMA (saline: 5.4 +/- 1.6%, L-NMMA: 5.6 +/- 1.5%). Superficial femoral artery FMD in response to distal arterial occlusion for a period of 5 min is predominantly mediated by NO in healthy men and in the extremely deconditioned legs of SCI individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.