ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2008
Enhanced severity of virus associated lower respiratory tract disease in asthma patients may not be associated with delayed viral clearance and increased viral load in the upper respiratory tract.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Lessons learned from a double-blind randomised placebo-controlled study with a iota-carrageenan nasal spray as medical device in children with acute symptoms of common cold.BMC complementary and alternative medicine · 2012Trial
- Article
- [Expression of interferon-λ1 in respiratory epithelial cells in children with human rhinovirus infection].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Article
- Impact of community respiratory viral infections in urban children with asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019Article
- Clinical characteristics and cytokine profiles of children with acute lower respiratory tract infections caused by human rhinovirus.PloS one · 2018Article
- Influenza Virus Detection Following Administration of Live-Attenuated Intranasal Influenza Vaccine in Children With Cystic Fibrosis and Their Healthy Siblings.Open forum infectious diseases · 2016Article
- Clinical characteristics of asthmatic patients with influenza-like illness and risk of severe exacerbations in Mexico.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2016Article
- Inflammation and infections in asthma.The clinical respiratory journal · 2015Review
- Nasal lavage VEGF and TNF-α levels during a natural cold predict asthma exacerbations.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2014Article
- Asthma increases susceptibility to heterologous but not homologous secondary influenza.Journal of virology · 2014Article
- Impact of rhinovirus nasopharyngeal viral load and viremia on severity of respiratory infections in children.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Article
- Article
- The significance of rhinovirus detection in hospitalized children: clinical, epidemiological and virological features.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2013Article
- Vitamin D in asthma and future perspectives.Drug design, development and therapy · 2013Review
- Lower airway rhinovirus burden and the seasonal risk of asthma exacerbation.American journal of respiratory and critical care medicine · 2011Article
- Frequent detection of respiratory viruses without symptoms: toward defining clinically relevant cutoff values.Journal of clinical microbiology · 2011Article
- Article
- Interleukin-13-induced mucous metaplasia increases susceptibility of human airway epithelium to rhinovirus infection.American journal of respiratory cell and molecular biology · 2010Article
- Molecular quantification of respiratory syncytial virus in respiratory samples: reliable detection during the initial phase of infection.Journal of clinical microbiology · 2010Article
- Recurrent and persistent respiratory tract viral infections in patients with primary hypogammaglobulinemia.The Journal of allergy and clinical immunology · 2010Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundViral respiratory infections, particularly human rhinovirus (HRV) infections, are the most common cause of asthma exacerbation. HRV infections usually lead to more severe and longer duration of lower respiratory tract (LRT) symptoms in asthmatics than in otherwise healthy individuals. However, the exact mechanism by which viruses contribute to exacerbation of asthma is unknown.
objectivesThe main objective of our study was to investigate the relationship of the enhanced severity of LRT symptoms to viral dynamics or cytokine responses in the upper respiratory tract (URT). STUDY
designTherefore, we conducted a longitudinal study in which asthmatics and healthy controls were followed during natural viral respiratory tract infections.
resultsOur study confirmed that viral respiratory tract infections caused more severe problems of the LRT in asthma patients as compared to healthy controls. However, for all subjects, the severity of LRT symptoms were not related to viral load or prolonged viral shedding in the URT. In addition, we did not detect differences in proinflammatory cytokines in the URT between asthmatics and controls.
conclusionPersistence of the virus, as well as viral load in the URT, may not be associated with the induction and/or persistence of asthmatic symptoms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.