ArticleBMC molecular biology2007
Differential regulation of NAB corepressor genes in Schwann cells.
Article in BMC molecular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Molecular Mediators Associated With Myelination, Demyelination, and Remyelination in the Peripheral Nervous System.Journal of the peripheral nervous system : JPNS · 2026Review
- Article
- Unravelling axonal transcriptional landscapes: insights from induced pluripotent stem cell-derived cortical neurons and implications for motor neuron degeneration.Open biology · 2025Article
- Neuron-Schwann cell interactions in peripheral nervous system homeostasis, disease, and preclinical treatment.Frontiers in cellular neuroscience · 2023Review
- Insights Into the Role and Potential of Schwann Cells for Peripheral Nerve Repair From Studies of Development and Injury.Frontiers in molecular neuroscience · 2020Article
- Immediate Early Genes Anchor a Biological Pathway of Proteins Required for Memory Formation, Long-Term Depression and Risk for Schizophrenia.Frontiers in behavioral neuroscience · 2018Article
- Nab2 maintains thymus cellularity with aging and stress.Molecular immunology · 2017Article
- A RET-ER81-NRG1 Signaling Pathway Drives the Development of Pacinian Corpuscles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- An essential role of MAG in mediating axon-myelin attachment in Charcot-Marie-Tooth 1A disease.Neurobiology of disease · 2013Article
- Regulation of Schwann cell differentiation and proliferation by the Pax-3 transcription factor.Glia · 2012Article
- Genome-wide analysis of EGR2/SOX10 binding in myelinating peripheral nerve.Nucleic acids research · 2012Article
- Effective generation of transgenic reporter and gene trap lines of the medaka (Oryzias latipes) using the Ac/Ds transposon system.Transgenic research · 2012Article
- Locus-wide identification of Egr2/Krox20 regulatory targets in myelin genes.Journal of neurochemistry · 2010Article
- EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin.Journal of cellular biochemistry · 2010Article
- Krox20 controls the transcription of its various targets in the developing hindbrain according to multiple modes.The Journal of biological chemistry · 2009Article
- Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation.Science (New York, N.Y.) · 2009Article
- Review
- Toxoplasma gondii rhoptry discharge correlates with activation of the early growth response 2 host cell transcription factor.Infection and immunity · 2008Article
- Active gene repression by the Egr2.NAB complex during peripheral nerve myelination.The Journal of biological chemistry · 2008Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMyelination of peripheral nerves by Schwann cells requires not only the Egr2/Krox-20 transactivator, but also the NGFI-A/Egr-binding (NAB) corepressors, which modulate activity of Egr2. Previous work has shown that axon-dependent expression of Egr2 is mediated by neuregulin stimulation, and NAB corepressors are co-regulated with Egr2 expression in peripheral nerve development. NAB corepressors have also been implicated in macrophage development, cardiac hypertrophy, prostate carcinogenesis, and feedback regulation involved in hindbrain development.
resultsTo test the mechanism of NAB regulation in Schwann cells, transfection assays revealed that both Nab1 and Nab2 promoters are activated by Egr2 expression. Furthermore, direct binding of Egr2 at these promoters was demonstrated in vivo by chromatin immunoprecipitation analysis of myelinating sciatic nerve, and binding of Egr2 to the Nab2 promoter was stimulated by neuregulin in primary Schwann cells. Although Egr2 expression activates the Nab2 promoter more highly than Nab1, we surprisingly found that only Nab1 - but not Nab2 - expression levels were reduced in sciatic nerve from Egr2 null mice. Analysis of the Nab2 promoter showed that it is also activated by ETS proteins (Ets2 and Etv1/ER81) and is bound by Ets2 in vivo.
conclusionOverall, these results indicate that induction of Nab2 expression in Schwann cells involves not only Egr2, but also ETS proteins that are activated by neuregulin stimulation. Although Nab1 and Nab2 play partially redundant roles, regulation of Nab2 expression by ETS factors explains several observations regarding regulation of NAB genes. Finally, these data suggest that NAB proteins are not only feedback inhibitors of Egr2, but rather that co-induction of Egr2 and NAB genes is involved in forming an Egr2/NAB complex that is crucial for regulation of gene expression.
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