ArticleProteome science2007
Surface antigens and potential virulence factors from parasites detected by comparative genomics of perfect amino acid repeats.
Article in Proteome science, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Structural and functional insights from detailed computational analysis ofJournal of genetics · 2026Article
- Two short low complexity regions (LCRs) are hallmark sequences of the Delta SARS-CoV-2 variant spike protein.Scientific reports · 2022Article
- Whole genome sequencing of Entamoeba nuttalli reveals mammalian host-related molecular signatures and a novel octapeptide-repeat surface protein.PLoS neglected tropical diseases · 2019Article
- Structural analysis of P. falciparum KAHRP and PfEMP1 complexes with host erythrocyte spectrin suggests a model for cytoadherent knob protrusions.PLoS pathogens · 2017Article
- Down Modulation of Host Immune Response by Amino Acid Repeats Present in aFrontiers in microbiology · 2017Article
- Expansion of Lysine-rich Repeats in Plasmodium Proteins Generates Novel Localization Sequences That Target the Periphery of the Host Erythrocyte.The Journal of biological chemistry · 2016Article
- Understanding and identifying amino acid repeats.Briefings in bioinformatics · 2014Article
- The genome of Spraguea lophii and the basis of host-microsporidian interactions.PLoS genetics · 2013Article
- Reduction and expansion in microsporidian genome evolution: new insights from comparative genomics.Genome biology and evolution · 2013Article
- Homepeptide repeats: implications for protein structure, function and evolution.Genomics, proteomics & bioinformatics · 2012Article
- The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.PLoS pathogens · 2012Article
- Genome-wide survey and analysis of microsatellites in nematodes, with a focus on the plant-parasitic species Meloidogyne incognita.BMC genomics · 2010Article
- A versatile palindromic amphipathic repeat coding sequence horizontally distributed among diverse bacterial and eucaryotic microbes.BMC genomics · 2010Article
- Trichomonas vaginalis vast BspA-like gene family: evidence for functional diversity from structural organisation and transcriptomics.BMC genomics · 2010Article
- Transcriptome analysis of the Cryptocaryon irritans tomont stage identifies potential genes for the detection and control of cryptocaryonosis.BMC genomics · 2010Article
- Modular architecture and evolution of the map-1 gene family in the root-knot nematode Meloidogyne incognita.Molecular genetics and genomics : MGG · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany parasitic organisms, eukaryotes as well as bacteria, possess surface antigens with amino acid repeats. Making up the interface between host and pathogen such repetitive proteins may be virulence factors involved in immune evasion or cytoadherence. They find immunological applications in serodiagnostics and vaccine development. Here we use proteins which contain perfect repeats as a basis for comparative genomics between parasitic and free-living organisms.
resultsWe have developed Reptile http://reptile.unibe.ch, a program for proteome-wide probabilistic description of perfect repeats in proteins. Parasite proteomes exhibited a large variance regarding the proportion of repeat-containing proteins. Interestingly, there was a good correlation between the percentage of highly repetitive proteins and mean protein length in parasite proteomes, but not at all in the proteomes of free-living eukaryotes. Reptile combined with programs for the prediction of transmembrane domains and GPI-anchoring resulted in an effective tool for in silico identification of potential surface antigens and virulence factors from parasites.
conclusionSystemic surveys for perfect amino acid repeats allowed basic comparisons between free-living and parasitic organisms that were directly applicable to predict proteins of serological and parasitological importance. An on-line tool is available at http://genomics.unibe.ch/dora.
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