Trial reportHuman brain mapping2009
Late evening brain activation patterns and their relation to the internal biological time, melatonin, and homeostatic sleep debt.
Trial report in Human brain mapping, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Efficacy of non-pharmacological interventions for sleep quality in Parkinson's disease: a systematic review and network meta-analysis.Frontiers in neuroscience · 2024Pooled it
- Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: a 6-month, randomized, placebo-controlled, multicenter trial.Clinical interventions in aging · 2014Trial
- Effectiveness of Early Cardiorespiratory Rehabilitation Combined With Melatonin Supplementation During the Inpatient Period After Acute Myocardial Infarction: a Pilot Study.Archives of rehabilitation research and clinical translation · 2025Article
- Impact of neuromodulation on excessive daytime sleepiness: a narrative review.Frontiers in psychiatry · 2025Review
- Parkinson's Disease: A Narrative Review on Potential Molecular Mechanisms of Sleep Disturbances, REM Behavior Disorder, and Melatonin.Brain sciences · 2023Review
- Human circadian rhythm studies: Practical guidelines for inclusion/exclusion criteria and protocol.Neurobiology of sleep and circadian rhythms · 2022Review
- Article
- Effect of jet lag on brain white matter functional connectivity.Psychoradiology · 2021Article
- Key Intrinsic Connectivity Networks for Individual Identification With Siamese Long Short-Term Memory.Frontiers in neuroscience · 2021Article
- The effect of jet lag on the human brain: A neuroimaging study.Human brain mapping · 2020Article
- Beyond the Low Frequency Fluctuations: Morning and Evening Differences in Human Brain.Frontiers in human neuroscience · 2019Article
- New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation.British journal of pharmacology · 2018Review
- Residual effects of emotion are reflected in enhanced visual activity after sleep.Cognitive, affective & behavioral neuroscience · 2017Article
- Age-related Changes in the Sleep-dependent Reorganization of Declarative Memories.Journal of cognitive neuroscience · 2016Article
- The circadian regulation of sleep: impact of a functional ADA-polymorphism and its association to working memory improvements.PloS one · 2014Article
- How cognitive neuroscience could be more biological-and what it might learn from clinical neuropsychology.Frontiers in human neuroscience · 2014Article
- Efficacy and safety of prolonged-release melatonin in insomnia patients with diabetes: a randomized, double-blind, crossover study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2011 · on this mapArticle
- New approaches in the management of insomnia: weighing the advantages of prolonged-release melatonin and synthetic melatoninergic agonists.Neuropsychiatric disease and treatment · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep propensity increases sharply at night. Some evidence implicates the pineal hormone melatonin in this process. Using functional magnetic resonance imaging, brain activation during a visual search task was examined at 22:00 h (when endogenous melatonin levels normally increase). The relationships between brain activation, endogenous melatonin (measured in saliva), and self-reported fatigue were assessed. Finally, the effects of exogenous melatonin administered at 22:00 h were studied in a double blind, placebo-controlled crossover manner. We show that brain activation patterns as well as the response to exogenous melatonin significantly differ at night from those seen in afternoon hours. Thus, activation in the rostro-medial and lateral aspects of the occipital cortex and the thalamus diminished at 22:00 h. Activation in the right parietal cortex increased at night and correlated with individual fatigue levels, whereas exogenous melatonin given at 22:00 h reduced activation in this area. The right dorsolateral prefrontal cortex, an area considered to reflect homeostatic sleep debt, demonstrated increased activation at 22:00 h. Surprisingly, this increase correlated with endogenous melatonin. These results demonstrate and partially differentiate circadian effects (whether mediated by melatonin or not) and homeostatic sleep debt modulation of human brain activity associated with everyday fatigue at night.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.