ArticleJournal of bone and mineral metabolism2008
Alendronate treatment promotes bone formation with a less anisotropic microstructure during intramembranous ossification in rats.
Article in Journal of bone and mineral metabolism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- A Randomized Controlled Trial Evaluating the Effect of Local Application of Sodium Alendronate Gel and Low-Level Laser Therapy (LLLT) On Peri-Implant Tissue Healing in Wistar Rats.F1000Research · 2025Article
- The influence of immediate occlusal loading on micro/nano-structure of peri-implant jaw bone in rats.International journal of implant dentistry · 2024Article
- Deterioration of apatite orientation in the cholecystokinin B receptor gene (Cckbr)-deficient mouse femurs.Journal of bone and mineral metabolism · 2023Article
- Exploring the Potential of Nanotechnology in Pediatric Healthcare: Advances, Challenges, and Future Directions.Pharmaceutics · 2023Review
- Periodontal Tissue as a Biomaterial for Hard-Tissue Regeneration followingMaterials (Basel, Switzerland) · 2022Article
- Superior Alignment of Human iPSC-Osteoblasts Associated with Focal Adhesion Formation Stimulated by Oriented Collagen Scaffold.International journal of molecular sciences · 2021Article
- Live Fluorescent Staining Platform for Drug-Screening and Mechanism-Analysis in Zebrafish for Bone Mineralization.Molecules (Basel, Switzerland) · 2017Article
- The Therapeutic Effects of Combination Therapy with Curcumin and Alendronate on Spine Fusion Surgery in the Ovariectomized Rats.Korean Journal of Spine · 2017Article
- Femoral neck fractures in osteogenesis imperfecta treated with bisphosphonates.Journal of children's orthopaedics · 2017Article
- Crystallographic orientation of the c-axis of biological apatite as a new index of the quality of subchondral bone in knee joint osteoarthritis.Journal of bone and mineral metabolism · 2017Article
- The influence of low-level laser therapy with alendronate irrigation on healing of bone defects in rats.Lasers in medical science · 2015Article
- Therapeutic advantages of treatment of high-dose curcumin in the ovariectomized rat.Journal of Korean Neurosurgical Society · 2013Article
- Changing pattern of femoral fractures in osteogenesis imperfecta with prolonged use of bisphosphonates.Journal of children's orthopaedics · 2012Article
- Biomimetic coating of bisphosphonate incorporated CDHA on Ti6Al4V.Journal of materials science. Materials in medicine · 2012Article
- Periodontal disease and bisphosphonates induce osteonecrosis of the jaws in the rat.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
- The combination therapy with alfacalcidol and risedronate improves the mechanical property in lumbar spine by affecting the material properties in an ovariectomized rat model of osteoporosis.BMC musculoskeletal disorders · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are safety concerns regarding administration of bisphosphonates to children. Little is known about the effects of bisphosphonates on bone matrix organization during bone modeling. The present study examined the effects of alendronate (ALN) on bone matrices formed by intramembranous ossification in the appendicular growing skeleton. ALN was administered to 1-week-old Sprague-Dawley rats at a dose of 0, 35, or 350 microg/kg/week for 4 or 8 weeks. The position of femoral diaphysis formed exclusively by intramembranous ossification was identified, and cross sections of cortical bone at this position were analyzed. Bone mineral density (BMD) and geometric parameters were evaluated using peripheral quantitative computed tomography. The preferential orientation degree of biological apatite (BAp) crystals in the bone longitudinal direction, which shows the degree of bone matrix anisotropy, was evaluated using microbeam X-ray diffraction analysis. We analyzed bone histomorphometrical parameters and performed bone nanomechanical tests to examine the material properties of newly developing cortical bone. The preferential orientation degree of BAp crystals significantly decreased in 35 microg/kg/week ALN-treated groups compared with vehicle-treated groups, although there were no significant differences in BMD between the two groups. The periosteal mineral apposition rate significantly increased in the 35 microg/kg/week ALN-treated group. We found a high negative correlation between bone matrix anisotropy and the regional periosteal mineral apposition rate (r = -0.862, P < 0.001). Nanomechanical tests revealed that 35 microg/kg/week ALN administration caused deterioration of the material properties of the bone microstructure. These new findings suggest that alendronate affects bone matrix organization and promotes bone formation with a less anisotropic microstructure during intramembranous ossification.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.