Evidence map›Paper›PMID 18094461›Full record

ArticleActa crystallographica. Section D, Biological crystallography2008

An introduction to molecular replacement.

Philip Evans, Airlie McCoy

Open access · hybridAbstract read
In one paragraph

Article in Acta crystallographica. Section D, Biological crystallography, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 109 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. How the technologies behind self-driving cars, social networks, ChatGPT, and DALL-E2 are changing structural biology.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  6. AlphaFold-guided molecular replacement for solving challenging crystal structures.Acta crystallographica. Section D, Structural biology · 2025
    Article
  7. Article
  8. Deep learning applications in protein crystallography.Acta crystallographica. Section A, Foundations and advances · 2024
    Review
  9. Article
  10. Review
  11. Predicted models and CCP4.Acta crystallographica. Section D, Structural biology · 2023
    Article
  12. Article
  13. General Strategies for RNA X-ray Crystallography.Molecules (Basel, Switzerland) · 2023
    Review
  14. Structural Basis of the Inhibition of L-Methionine γ-Lyase fromInternational journal of molecular sciences · 2023
    Article
  15. Article
  16. Article
  17. The integration of AlphaFold-predicted and crystal structures of humanComputational and structural biotechnology journal · 2022
    Article
  18. Predicting the performance of automated crystallographic model-building pipelines.Acta crystallographica. Section D, Structural biology · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Philip EvansMRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, England. pre@mrc-lmb.ac.uk
Airlie McCoy
MRC Laboratory of Molecular Biology · GBUniversity of Cambridge · GB

Funding

Medical Research Council MC_U105178845
6 · The paper itself

Abstract

Molecular replacement is fundamentally a simple trial-and-error method of solving crystal structures when a suitable related model is available. The underlying simplicity of the method is often obscured by the mathematical trickery required to make the searches computationally tractable. This introduction sketches the essential issues in molecular replacement without going into technical details. General search strategies are discussed and the alternative Patterson and likelihood approaches are outlined.

Indexed as

AlgorithmsModels, MolecularComputer SimulationCrystallizationCrystallography, X-RayProtein ConformationProteinsProteins

Identifiers

PMID18094461
PMCPMC2394790
OpenAlexW2144795375

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.