ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
The impact of catechol-O-methyltransferase and dopamine D4 receptor genotypes on neurophysiological markers of performance monitoring.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
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Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Electrophysiological markers of genetic risk for attention deficit hyperactivity disorder.Expert reviews in molecular medicine · 2011Pooled it
- Event-related potentials reflect impaired temporal interval learning following haloperidol administration.Psychopharmacology · 2017Trial
- Preserved Error-Monitoring in Borderline Personality Disorder Patients with and without Non-Suicidal Self-Injury Behaviors.PloS one · 2015Trial
- Monoaminergic modulation of behavioural and electrophysiological indices of error processing.Psychopharmacology · 2014Trial
- The effects of acute abstinence from smoking and performance-based rewards on performance monitoring.Psychopharmacology · 2013Trial
- Acute dopamine depletion with branched chain amino acids decreases auditory top-down event-related potentials in healthy subjects.Schizophrenia research · 2009Trial
- Reward-based decision-making in mesial temporal lobe epilepsy patients with unilateral hippocampal sclerosis pre- and post-surgery.NeuroImage. Clinical · 2022Article
- The Role of Dopaminergic Genes in Probabilistic Reinforcement Learning in Schizophrenia Spectrum Disorders.Brain sciences · 2021Article
- First Demonstration of Double Dissociation between COMT-Met158 and COMT-Val158 Cognitive Performance When Stressed and When Calmer.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Dimensions of Craving Interact withBrain sciences · 2021Article
- Effects of Childhood Adversity and Its Interaction with the MAOA, BDNF, and COMT Polymorphisms on Subclinical Attention Deficit/Hyperactivity Symptoms in Generally Healthy Youth.Children (Basel, Switzerland) · 2020Article
- Relations between catechol-O-methyltransferase Val158Met genotype and inhibitory control development in childhood.Developmental psychobiology · 2020Article
- Patients with mutations of the Thyroid hormone beta-receptor show an ADHD-like phenotype for performance monitoring: an electrophysiological study.NeuroImage. Clinical · 2020Article
- Lifelong consequences of brain injuries during development: From risk to resilience.Frontiers in neuroendocrinology · 2019Review
- Error-Related Dynamics of Reaction Time and Frontal Midline Theta Activity in Attention Deficit Hyperactivity Disorder (ADHD) During a Subliminal Motor Priming Task.Frontiers in human neuroscience · 2019Article
- Neurobiology and clinical features of impulse control failure in Parkinson's disease.Neurological research and practice · 2019Review
- Methamphetamine Users Show No Behavioral Deficits in Response Selection After Protracted Abstinence.Frontiers in psychiatry · 2019Article
- EEG Source Imaging Indices of Cognitive Control Show Associations with Dopamine System Genes.Brain topography · 2018Article
- Performance monitoring in lung cancer patients pre- and post-chemotherapy using fine-grained electrophysiological measures.NeuroImage. Clinical · 2018Article
- Genetic variation of dopamine and serotonin function modulates the feedback-related negativity during altruistic punishment.Scientific reports · 2017Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Dynamic adaptations of one's behavior by means of performance monitoring are a central function of the human executive system, that underlies considerable interindividual variation. Converging evidence from electrophysiological and neuroimaging studies in both animals and humans hints at the importance of the dopaminergic system for the regulation of performance monitoring. Here, we studied the impact of two polymorphisms affecting dopaminergic functioning in the prefrontal cortex [catechol-O-methyltransferase (COMT) Val108/158Met and dopamine D4 receptor (DRD4) single-nucleotide polymorphism (SNP)-521] on neurophysiological correlates of performance monitoring. We applied a modified version of a standard flanker task with an embedded stop-signal task to tap into the different functions involved, particularly error monitoring, conflict detection and inhibitory processes. Participants homozygous for the DRD4 T allele produced an increased error-related negativity after both choice errors and failed inhibitions compared with C-homozygotes. This was associated with pronounced compensatory behavior reflected in higher post-error slowing. No group differences were seen in the incompatibility N2, suggesting distinct effects of the DRD4 polymorphism on error monitoring processes. Additionally, participants homozygous for the COMT Val allele, with a thereby diminished prefrontal dopaminergic level, revealed increased prefrontal processing related to inhibitory functions, reflected in the enhanced stop-signal-related components N2 and P3a. The results extend previous findings from mainly behavioral and neuroimaging data on the relationship between dopaminergic genes and executive functions and present possible underlying mechanisms for the previously suggested association between these dopaminergic polymorphisms and psychiatric disorders as schizophrenia or attention deficit hyperactivity disorder.
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