ArticleJournal of virology2008
CD4 T cells contribute to virus control and pathology following central nervous system infection with neurotropic mouse hepatitis virus.
Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The trial behind it
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Who cites it
30 citing papers in PubMed, 43 citations in OpenAlex.
- Intrathecally expanded GZMK+/GZMH+ CD8 T cells targeting EBV antigens may reduce severity of Multiple Sclerosis.medRxiv : the preprint server for health sciences · 2025Article
- T helper 1 effector memory CD4Cell reports · 2023Article
- Connecting Neuroinflammation and Neurodegeneration in Multiple Sclerosis: Are Oligodendrocyte Precursor Cells a Nexus of Disease?Frontiers in cellular neuroscience · 2021Review
- CD4 Deficiency Causes Poliomyelitis and Axonal Blebbing in Murine Coronavirus-Induced Neuroinflammation.Journal of virology · 2020Article
- Distinct Gene Profiles of Bone Marrow-Derived Macrophages and Microglia During Neurotropic Coronavirus-Induced Demyelination.Frontiers in immunology · 2018Article
- Viral-induced suppression of self-reactive T cells: Lessons from neurotropic coronavirus-induced demyelination.Journal of neuroimmunology · 2017Review
- CD4 and CD8 T cells mediate distinct lethal meningoencephalitis in mice challenged with Tacaribe arenavirus.Cellular & molecular immunology · 2017Article
- MicroRNA-155 enhances T cell trafficking and antiviral effector function in a model of coronavirus-induced neurologic disease.Journal of neuroinflammation · 2016Article
- Article
- Distinct CD4 T-cell effects on primary versus recall CD8 T-cell responses during viral encephalomyelitis.Immunology · 2015Article
- Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models.Acta neuropathologica · 2014Article
- Comprehensive immunophenotyping of cerebrospinal fluid cells in patients with neuroimmunological diseases.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- T cell mediated suppression of neurotropic coronavirus replication in neural precursor cells.Virology · 2014Article
- MMP-independent role of TIMP-1 at the blood brain barrier during viral encephalomyelitis.ASN neuro · 2013Article
- Astrocyte-derived CXCL10 drives accumulation of antibody-secreting cells in the central nervous system during viral encephalomyelitis.Journal of virology · 2013Article
- Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis.Journal of neuroinflammation · 2012Article
- IFN-γ protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophils.Journal of neuroinflammation · 2012Article
- CXCR2 signaling and host defense following coronavirus-induced encephalomyelitis.Future virology · 2012Article
- CD4 T cells promote CD8 T cell immunity at the priming and effector site during viral encephalitis.Journal of virology · 2012Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Replication of the neurotropic mouse hepatitis virus strain JHM (JHMV) is controlled primarily by CD8(+) T-cell effectors utilizing gamma interferon (IFN-gamma) and perforin-mediated cytotoxicity. CD4(+) T cells provide an auxiliary function(s) for CD8(+) T-cell survival; however, their direct contribution to control of virus replication and pathology is unclear. To examine a direct role of CD4(+) T cells in viral clearance and pathology, pathogenesis was compared in mice deficient in both perforin and IFN-gamma that were selectively reconstituted for these functions via transfer of virus-specific memory CD4(+) T cells. CD4(+) T cells from immunized wild-type, perforin-deficient, and IFN-gamma-deficient donors all initially reduced virus replication. However, prolonged viral control by IFN-gamma-competent donors suggested that IFN-gamma is important for sustained virus control. Local release of IFN-gamma was evident by up-regulation of class II molecules on microglia in recipients of IFN-gamma producing CD4(+) T cells. CD4(+) T-cell-mediated antiviral activity correlated with diminished clinical symptoms, pathology, and demyelination. Both wild-type donor CD90.1 and recipient CD90.2 CD4(+) T cells trafficked into the central nervous system (CNS) parenchyma and localized to infected white matter, correlating with decreased numbers of virus-infected oligodendrocytes in the CNS. These data support a direct, if limited, antiviral role for CD4(+) T cells early during acute JHMV encephalomyelitis. Although the antiviral effector mechanism is initially independent of IFN-gamma secretion, sustained control of CNS virus replication by CD4(+) T cells requires IFN-gamma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.