ReviewProceedings of the American Thoracic Society2008
Airway smooth muscle cell as an inflammatory cell: lessons learned from interferon signaling pathways.
Review in Proceedings of the American Thoracic Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Effects ofPlants (Basel, Switzerland) · 2023Article
- Novel Comprehensive Bioinformatics Approaches to Determine the Molecular Genetic Susceptibility Profile of Moderate and Severe Asthma.International journal of molecular sciences · 2020Article
- FGF2, an Immunomodulatory Factor in Asthma and Chronic Obstructive Pulmonary Disease (COPD).Frontiers in cell and developmental biology · 2020Review
- Effect of the plant derivative Compound A on the production of corticosteroid-resistant chemokines in airway smooth muscle cells.American journal of respiratory cell and molecular biology · 2015Article
- Refractory asthma: mechanisms, targets, and therapy.Allergy · 2014Review
- Functional KCa3.1 channels regulate steroid insensitivity in bronchial smooth muscle cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Caveolin-1 in cytokine-induced enhancement of intracellular Ca(2+) in human airway smooth muscle.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- T-bet is induced by interferon-γ to mediate chemokine secretion and migration in human airway smooth muscle cells.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- Interferons modulate mitogen-induced protein synthesis in airway smooth muscle.American journal of physiology. Lung cellular and molecular physiology · 2010Article
- Transcriptional regulation of cytokine function in airway smooth muscle cells.Pulmonary pharmacology & therapeutics · 2009Review
- Airway smooth muscle as an immunomodulatory cell.Pulmonary pharmacology & therapeutics · 2009Review
- Vitamin D and glucocorticoids differentially modulate chemokine expression in human airway smooth muscle cells.British journal of pharmacology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The present article will describe the potential role of airway smooth muscle (ASM) in mediating both deleterious/beneficial effects of interferons (IFNs) in asthma. First described as beneficial in treating the main features of asthma, the interplay between IFNs and ASM could explain their deleterious actions recently described in a number of different studies. Through multiple mechanisms, including the suppression of steroid action, the synergistic pro-inflammatory actions when combined with other cytokines, and the modulation of calcium metabolism, IFNs are now seen as critical mediators in the pathogenesis of asthma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.