Evidence map›Paper›PMID 18094084›Full record

ReviewProceedings of the American Thoracic Society2008

Regulation of heterotrimeric G protein signaling in airway smooth muscle.

Raymond B Penn, Jeffrey L Benovic

Open access · greenAbstract readReview
In one paragraph

Review in Proceedings of the American Thoracic Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 77 citations in OpenAlex.

  1. Article
  2. Channeling Relaxation through Multiple Means: TMEM16A Antagonism for Asthma.American journal of respiratory cell and molecular biology · 2025
    Article
  3. Diacylglycerol kinase is a keystone regulator of signaling relevant to the pathophysiology of asthma.American journal of physiology. Lung cellular and molecular physiology · 2024
    Review
  4. βBritish journal of pharmacology · 2022
    Article
  5. Article
  6. Article
  7. OGR1-dependent regulation of the allergen-induced asthma phenotype.American journal of physiology. Lung cellular and molecular physiology · 2021
    Article
  8. Article
  9. Article
  10. Can GPCRs Be Targeted to Control Inflammation in Asthma?Advances in experimental medicine and biology · 2021
    Article
  11. Article
  12. Dexamethasone rescues TGF-β1-mediated βRespiratory research · 2020
    Article
  13. Article
  14. G proteins: binary switches in health and disease.Central-European journal of immunology · 2020
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. PDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by βAmerican journal of respiratory cell and molecular biology · 2018
    Article
  20. RGS4 Overexpression in Lung Attenuates Airway Hyperresponsiveness in Mice.American journal of respiratory cell and molecular biology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Raymond B PennDepartment of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA. rpenn@wfubmc.edu
Jeffrey L Benovic
Thomas Jefferson University · USWake Forest University · US

Funding

G Protein-Coupled Receptor Signaling in Airway Smooth MuR01HL058506 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RAYMOND B. PENN · 2001 to 2026
$9.3M
G PROTEIN-COUPLED RECEPTOR KINASESR01GM044944 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI BENOVIC, JEFFREY L · 1990 to 2016
$5.3M
Role of Arrestins in G Protein-Coupled Receptor RegulationR37GM047417 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI BENOVIC, JEFFREY L · 2006 to 2015
$4.3M
ARRESTINS IN G PROTEIN-COUPLE RECEPTOR REGULATIONR01GM047417 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI BENOVIC, JEFFREY L · 1994 to 2005
$1.8M
Regulation of cysteinyl leukotriene type I receptorR01AI059755 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI PENN, RAYMOND B. · 2004 to 2007
$1.3M
BETA ADRENERGIC RECEPTOR REGULATION IN HUMAN AIRWAY MUSCR29HL058506 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI PENN, RAYMOND B. · 1997 to 2000
$113k
NHLBI NIH HHS HL58506NIAID NIH HHS AI59755NIGMS NIH HHS GM44944NIGMS NIH HHS GM47417
6 · The paper itself

Abstract

Heterotrimeric G proteins transduce signals from G protein-coupled receptors to regulate numerous signaling events and functions in airway smooth muscle (ASM). In this article, we detail the function and regulation of heterotrimeric G protein signaling in ASM. We further discuss recent advances in the development of experimental tools in the study of G protein signaling, and speculate how these tools might be used in therapeutic strategies that seek to mitigate bronchospasm and airway remodeling that occur in obstructive airway disease.

Indexed as

Signal TransductionAdrenergic beta-AgonistsAnimalsAsthmaGlucocorticoidsHumansMuscle, SmoothReceptors, G-Protein-CoupledRespiratory SystemAdrenergic beta-AgonistsGlucocorticoidsReceptors, G-Protein-Coupled

Identifiers

PMID18094084
PMCPMC2645302
OpenAlexW2143903809

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.