ArticleMolecular biology of the cell2008
Transforming growth factor beta controls the directional migration of hepatocyte cohorts by modulating their adhesion to fibronectin.
Article in Molecular biology of the cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Dual signaling pathways of TGF-β superfamily cytokines in hepatocytes: balancing liver homeostasis and disease progression.Frontiers in pharmacology · 2025Review
- Insulin increases type I collagen synthesis in hepatic stellate cells via α5β1 integrin.Metabolism and target organ damage · 2024Article
- Mesenchymal Stem Cells Attenuates TGF-β1-Induced EMT by Increasing HGF Expression in HK-2 Cells.Iranian journal of public health · 2021Article
- Modeling Liver Organogenesis by Recreating Three-Dimensional Collective Cell Migration: A Role for TGFβ Pathway.Frontiers in bioengineering and biotechnology · 2021Article
- TGF-β Family Signaling in Ductal Differentiation and Branching Morphogenesis.Cold Spring Harbor perspectives in biology · 2018Review
- TGF-β triggers rapid fibrillogenesis via a novel TβRII-dependent fibronectin-trafficking mechanism.Molecular biology of the cell · 2017Article
- Review
- Type XVIII collagen is essential for survival during acute liver injury in mice.Disease models & mechanisms · 2013Article
- NG2 regulates directional migration of oligodendrocyte precursor cells via Rho GTPases and polarity complex proteins.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Lymphotoxin signaling is initiated by the viral polymerase in HCV-linked tumorigenesis.PLoS pathogens · 2013Article
- Decreased tumor progression and invasion by a novel anti-cell motility target for human colorectal carcinoma cells.PloS one · 2013Article
- Plasma rich in growth factors (PRGF-Endoret) stimulates tendon and synovial fibroblasts migration and improves the biological properties of hyaluronic acid.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2012Article
- Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.World journal of experimental medicine · 2012Article
- Mechanical compression drives cancer cells toward invasive phenotype.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- TGF-β in progression of liver disease.Cell and tissue research · 2012Review
- Efficient differentiation of embryonic stem cells into hepatic cells in vitro using a feeder-free basement membrane substratum.PloS one · 2011Article
- TGF-b2 induction regulates invasiveness of Theileria-transformed leukocytes and disease susceptibility.PLoS pathogens · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transforming growth factor beta (TGF-beta) has a strong impact on liver development and physiopathology, exercised through its pleiotropic effects on growth, differentiation, survival, and migration. When exposed to TGF-beta, the mhAT3F cells, immortalized, highly differentiated hepatocytes, maintained their epithelial morphology and underwent dramatic alterations of adhesion, leading to partial or complete detachment from a culture plate, followed by readhesion and spreading. These alterations of adhesive behavior were caused by sequential changes in expression of the alpha5beta1 integrin and of its ligand, the fibronectin. The altered specificity of anchorage to the extracellular matrix gave rise to changes in cells' collective motility: cohorts adhering to fibronectin maintained a persistent, directional motility, with ezrin-rich pathfinder cells protruding from the tips of the cohorts. The absence of adhesion to fibronectin prevented the appearance of polarized pathfinders and lead to random, oscillatory motility. Our data suggest a novel role for TGF-beta in the control of collective migration of epithelial cohorts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.