ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2008
Multiplex real-time PCR for detection of respiratory tract infections.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02644135 (A Pilot Study of the Safety, Tolerability, and Effectiveness of Halo to Prevent Acute Upper Respiratory Disease and Respiratory Virus Infections), which is not on this map. Cited by 114 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Study of the Safety, Tolerability, and Effectiveness of Halo to Prevent Acute Upper Respiratory Disease and Respiratory Virus Infections
Who cites it
114 citing papers in PubMed, 217 citations in OpenAlex.
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- Viral etiology of acute respiratory infections in hospitalized children in Novosibirsk City, Russia (2013 - 2017).PloS one · 2018Trial
- Randomized, double-blind, placebo-controlled clinical trial to assess the safety and effectiveness of a novel dual-action oral topical formulation against upper respiratory infections.BMC infectious diseases · 2017Trial
- Access to a polymerase chain reaction assay method targeting 13 respiratory viruses can reduce antibiotics: a randomised, controlled trial.BMC medicine · 2011Trial
- High-throughput multiplex detection of respiratory pathogens: multicenter evaluation of the NxTAG Respiratory Pathogen Panel v2 assay.Journal of clinical microbiology · 2026Article
- Molecular Epidemiology of Human Metapneumovirus in Kilifi, Coastal Kenya, 2016-2017 and 2021-2024.Wellcome open research · 2026Article
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- Incidence of respiratory viral infections in adults following hematopoietic stem cell transplant (HSCT) at a tertiary care hospital in India.Virusdisease · 2025Article
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- Etiological analysis of acute respiratory infections in hospitalized children after the relaxation of COVID-19 non-pharmacological interventions in Quzhou, China.BMC infectious diseases · 2024Article
- Biomarkers and genotypes in patients with Central nervous system infection caused by enterovirus.Infectious diseases (London, England) · 2024Article
- Acute Respiratory Tract Infections (ARTIs) in Children after COVID-19-Related Social Distancing: An Epidemiological Study in a Single Center of Southern Italy.Diagnostics (Basel, Switzerland) · 2024Article
- Clinical Spectrum and Epidemiology of Human Parechovirus Infections in Infants: A Retrospective Study in the Western Part of Sweden.Open forum infectious diseases · 2024Article
- Prevalence of Endemic Respiratory Viruses During the COVID-19 Pandemic in Urban and Rural Malawi.Open forum infectious diseases · 2024Article
- The use and usefulness of point-of-care tests in patients with pharyngotonsillitis - an observational study in primary health care.BMC primary care · 2024Observational
- Establishment and evaluation of MIRA-qPCR assay for the rapid and sensitively detection ofFuture microbiology · 2024Article
- Testing the limits of multiplex respiratory virus assays for SARS-CoV-2 at high cycle threshold values: Comparative performance of cobas 6800/8800 SARS-CoV-2 & Influenza A/B, Xpert Xpress SARS-CoV-2/Flu/RSV, and cobas Liat SARS-CoV-2 & Influenza A/B.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2024Article
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- A fully integrated duplex RT-LAMP device for the detection of viral infections.Biomedical microdevices · 2023Article
- High incidence of the virus among respiratory pathogens in children with lower respiratory tract infection in northwestern China.Journal of medical virology · 2023Article
54 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBroad diagnostics of respiratory infection by molecular assays has not yet won acceptance due to technical difficulties and high costs.
objectivesTo evaluate clinical applicability of multiplex real-time PCR. STUDY
designAn assay targeting influenza virus A (IfA) and B (IfB), parainfluenza 1-3 (PIV), human metapneumovirus (MPV), respiratory syncytial virus (RSV), rhinovirus (RV), enterovirus (EV), adenovirus (AdV), human coronaviruses (229E, OC43, NL63), M. pneumoniae and Ch. pneumoniae was developed and run daily on consecutive clinical nasopharyngeal swab samples.
resultsAn etiology was identified in 48% of the 954 samples, with IfA in 25%, RV in 20%, MPV in 10% and M. pneumoniae in 10% of the positive. By a rational procedure costs could be reduced and the customer price set relatively low (euro33 per sample).
conclusionStreamlined testing and cost limitation is achievable and probably critical for implementation of a broad molecular diagnostics of respiratory infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.