ArticleNeuron2007
HCN1 channels constrain synaptically evoked Ca2+ spikes in distal dendrites of CA1 pyramidal neurons.
Article in Neuron, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers, 1 of them a synthesis that pooled it.
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Who cites it
128 citing papers in PubMed, 1 synthesis or guideline pooled it, 218 citations in OpenAlex.
- The Contribution of HCN Channelopathies in Different Epileptic Syndromes, Mechanisms, Modulators, and Potential Treatment Targets: A Systematic Review.Frontiers in molecular neuroscience · 2022Pooled it
- Enhanced HCN-Dependent Regulation of Temporoammonic Integration and Entorhinal-Hippocampal Epileptiform Coupling Following Febrile Seizures.Neurochemical research · 2026Article
- Dendritic Inhibition Terminates Plateau Potentials in CA1 Pyramidal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- HCN1 is a primary HCN Pacemaker Channel in Neurons.Nature communications · 2026Article
- NPAS4 refines spatial and temporal firing in CA1 pyramidal neurons.bioRxiv : the preprint server for biology · 2026Article
- Behavioral timescale synaptic plasticity: properties, elements and functions.Nature neuroscience · 2026Review
- Intrinsic Dendritic Integration Features of Prefrontal Layer 5 Pyramidal Cell Subclasses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Hippocampal dorsal CA1: Functional connectivity and role in HCN channelopathies in affective diseases and epilepsy.IBRO neuroscience reports · 2025Article
- Dendritic excitations govern back-propagation via a spike-rate accelerometer.Nature communications · 2025Article
- Sub-cellular population imaging tools reveal stable apical dendrites in hippocampal area CA3.Nature communications · 2025Article
- Hyperpolarization-activated cyclic nucleotide-gated channels and epilepsy: genetics, circuits, and treatments.Frontiers in neurology · 2025Review
- Tau-mediated synaptic dysfunction is coupled with HCN channelopathy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Variable recruitment of distal tuft dendrites shapes new hippocampal place fields.bioRxiv : the preprint server for biology · 2024Article
- Dendritic excitations govern back-propagation via a spike-rate accelerometer.bioRxiv : the preprint server for biology · 2024Article
- Regulation of specific abnormal calcium signals in the hippocampal CA1 and primary cortex M1 alleviates the progression of temporal lobe epilepsy.Neural regeneration research · 2024Article
- Glia instruct axon regeneration via a ternary modulation of neuronal calcium channels in Drosophila.Nature communications · 2023Article
- HCN2 Channels in the Ventral Hippocampal CA1 Regulate Nociceptive Hypersensitivity in Mice.International journal of molecular sciences · 2023Article
- The Impact of Altered HCN1 Expression on Brain Function and Its Relationship with Epileptogenesis.Current neuropharmacology · 2023Review
- Excitatory and inhibitory effects of HCN channel modulation on excitability of layer V pyramidal cells.PLoS computational biology · 2022Article
68 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
HCN1 hyperpolarization-activated cation channels act as an inhibitory constraint of both spatial learning and synaptic integration and long-term plasticity in the distal dendrites of hippocampal CA1 pyramidal neurons. However, as HCN1 channels provide an excitatory current, the mechanism of their inhibitory action remains unclear. Here we report that HCN1 channels also constrain CA1 distal dendritic Ca2+ spikes, which have been implicated in the induction of LTP at distal excitatory synapses. Our experimental and computational results indicate that HCN1 channels provide both an active shunt conductance that decreases the temporal integration of distal EPSPs and a tonic depolarizing current that increases resting inactivation of T-type and N-type voltage-gated Ca2+ channels, which contribute to the Ca2+ spikes. This dual mechanism may provide a general means by which HCN channels regulate dendritic excitability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.