Evidence map›Paper›PMID 18093328›Full record

ArticleBMC bioinformatics2007

PARPs database: a LIMS systems for protein-protein interaction data mining or laboratory information management system.

Arnaud Droit, Joanna M Hunter, Michèle Rouleau, Chantal Ethier, Aude Picard-Cloutier, David Bourgais, Guy G Poirier

Abstract read
In one paragraph

Article in BMC bioinformatics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Transcriptional roles of PARP1 in cancer.Molecular cancer research : MCR · 2014
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Arnaud DroitHealth and Environment Unit, Laval University Medical research Center, CHUQ, Québec, Canada. arnaud.droit@gmail.com
Joanna M Hunter
Michèle Rouleau
Chantal Ethier
Aude Picard-Cloutier
David Bourgais
Guy G Poirier

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn the "post-genome" era, mass spectrometry (MS) has become an important method for the analysis of proteins and the rapid advancement of this technique, in combination with other proteomics methods, results in an increasing amount of proteome data. This data must be archived and analysed using specialized bioinformatics tools. DESCRIPTION: We herein describe "PARPs database," a data analysis and management pipeline for liquid chromatography tandem mass spectrometry (LC-MS/MS) proteomics. PARPs database is a web-based tool whose features include experiment annotation, protein database searching, protein sequence management, as well as data-mining of the peptides and proteins identified.

conclusionUsing this pipeline, we have successfully identified several interactions of biological significance between PARP-1 and other proteins, namely RFC-1, 2, 3, 4 and 5.

Indexed as

Database Management SystemsDatabases, ProteinBinding SitesChromatography, High Pressure LiquidComputational BiologyInformation Storage and RetrievalMass SpectrometryPoly (ADP-Ribose) Polymerase-1Poly(ADP-ribose) PolymerasesProtein BindingProtein Interaction MappingPARP1 protein, humanPoly (ADP-Ribose) Polymerase-1Poly(ADP-ribose) Polymerases

Identifiers

PMID18093328
PMCPMC2266781

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.