Evidence map›Paper›PMID 18093316›Full record

ArticleBMC cancer2007

Meat, vegetables and genetic polymorphisms and the risk of colorectal carcinomas and adenomas.

Camilla F Skjelbred, Mona Saebø, Anette Hjartåker, Tom Grotmol, Inger-Lise Hansteen, Kjell M Tveit, Geir Hoff, Elin H Kure

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 10 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 10 syntheses or guidelines pooled it, 60 citations in OpenAlex.

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  8. System review and metaanalysis of the relationships between five metabolic gene polymorphisms and colorectal adenoma risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012
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  17. A systemic review of glutathione S-transferase P1 Ile105Val polymorphism and colorectal cancer risk.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2014
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Camilla F SkjelbredDepartment of Laboratory Medicine, Section of Medical Genetics, Telemark Hospital, N-3710 Skien, Norway. camilla-furu.skjelbred@sthf.no
Mona Saebø
Anette Hjartåker
Tom Grotmol
Inger-Lise Hansteen
Kjell M Tveit
Geir Hoff
Elin H Kure
Cancer Registry of Norway · NOTelemark Hospital · NOTelemark Research Institute · NOOslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe risk of sporadic colorectal cancer (CRC) is mainly associated with lifestyle factors, particularly dietary factors. Diets high in red meat and fat and low in fruit and vegetables are associated with an increased risk of CRC. The dietary effects may be modulated by genetic polymorphisms in biotransformation genes. In this study we aimed to evaluate the role of dietary factors in combination with genetic factors in the different stages of colorectal carcinogenesis in a Norwegian population.

methodsWe used a case-control study design (234 carcinomas, 229 high-risk adenomas, 762 low-risk adenomas and 400 controls) to test the association between dietary factors (meat versus fruit, berries and vegetables) genetic polymorphisms in biotransformation genes (GSTM1, GSTT1, GSTP1 Ile105Val, EPHX1 Tyr113His and EPHX1 His139Arg), and risk of colorectal carcinomas and adenomas. Odds ratio (OR) and 95% confidence interval (95% CI) were estimated by binary logistic regression.

resultsA higher ratio of total meat to total fruit, berry and vegetable intake was positively associated with both high and low-risk adenomas, with approximately twice the higher risk in the 2nd quartile compared to the lowest quartile. For the high-risk adenomas this positive association was more obvious for the common allele (Tyr allele) of the EPHX1 codon 113 polymorphism. An association was also observed for the EPHX1 codon 113 polymorphism in the low-risk adenomas, although not as obvious.

conclusionAlthough, the majority of the comparison groups are not significant, our results suggest an increased risk of colorectal adenomas in individuals for some of the higher ratios of total meat to total fruit, berry and vegetable intake. In addition the study supports the notion that the biotransformation enzymes GSTM1, GSTP1 and EPHX1 may modify the effect of dietary factors on the risk of developing colorectal carcinoma and adenoma.

Indexed as

MeatPolymorphism, GeneticVegetablesAdenomaAgedCarcinomaCase-Control StudiesCohort StudiesColorectal NeoplasmsEatingEpoxide HydrolasesFemaleGlutathione S-Transferase piGlutathione TransferaseHumansMaleEPHX1 protein, humanEpoxide HydrolasesGlutathione S-Transferase piglutathione S-transferase T1Glutathione TransferaseGSTP1 protein, human

Identifiers

PMID18093316
PMCPMC2228310
OpenAlexW2003787532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.