ArticleBMC genomics2007
Serial Analysis of Gene Expression in Plasmodium berghei salivary gland sporozoites.
Article in BMC genomics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Avian malaria and the overlooked metabolic pathways underlying mosquitoRoyal Society open science · 2025Article
- Peptides with Antimicrobial Activity in the Saliva of the Malaria VectorInternational journal of molecular sciences · 2024Article
- Single-cell RNA sequencing reveals developmental heterogeneity among Plasmodium berghei sporozoites.Scientific reports · 2021Article
- Systems Biology-Based Investigation of Host-Plasmodium Interactions.Trends in parasitology · 2018Review
- An in vitro assay to measure antibody-mediated inhibition of P. berghei sporozoite invasion against P. falciparum antigens.Scientific reports · 2017Article
- A Novel and Conserved Plasmodium Sporozoite Membrane Protein SPELD is Required for Maturation of Exo-erythrocytic Forms.Scientific reports · 2017Article
- Plasmodium falciparum infection induces expression of a mosquito salivary protein (Agaphelin) that targets neutrophil function and inhibits thrombosis without impairing hemostasis.PLoS pathogens · 2014Article
- Tissue signatures influence the activation of intrahepatic CD8(+) T cells against malaria sporozoites.Frontiers in microbiology · 2014Review
- Identification of targets of CD8⁺ T cell responses to malaria liver stages by genome-wide epitope profiling.PLoS pathogens · 2013Article
- Tricks in Plasmodium's molecular repertoire--escaping 3'UTR excision-based conditional silencing of the chloroquine resistance transporter gene.International journal for parasitology · 2012Article
- Sterile protective immunity to malaria is associated with a panel of novel P. falciparum antigens.Molecular & cellular proteomics : MCP · 2011Article
- FLP/FRT-mediated conditional mutagenesis in pre-erythrocytic stages of Plasmodium berghei.Nature protocols · 2011Article
- Plasmodium immunomics.International journal for parasitology · 2011Review
- Proteomic profiling of Plasmodium sporozoite maturation identifies new proteins essential for parasite development and infectivity.PLoS pathogens · 2008Article
- A sporozoite asparagine-rich protein controls initiation of Plasmodium liver stage development.PLoS pathogens · 2008Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundThe invasion of Anopheles salivary glands by Plasmodium sporozoites is an essential step for transmission of the parasite to the vertebrate host. Salivary gland sporozoites undergo a developmental programme to express genes required for their journey from the site of the mosquito bite to the liver and subsequent invasion of, and development within, hepatocytes. A Serial Analysis of Gene Expression was performed on Anopheles gambiae salivary glands infected or not with Plasmodium berghei and we report here the analysis of the Plasmodium sporozoite transcriptome.
resultsAnnotation of 530 tag sequences homologous to Plasmodium berghei genomic sequences identified 123 genes expressed in salivary gland sporozoites and these genes were classified according to their transcript abundance. A subset of these genes was further studied by quantitative PCR to determine their expression profiles. This revealed that sporozoites modulate their RNA amounts not only between the midgut and salivary glands, but also during their storage within the latter. Among the 123 genes, the expression of 66 is described for the first time in sporozoites of rodent Plasmodium species.
conclusionThese novel sporozoite expressed genes, especially those expressed at high levels in salivary gland sporozoites, are likely to play a role in Plasmodium infectivity in the mammalian host.
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