ArticleAnnals of human genetics2008
Shared genomic segment analysis. Mapping disease predisposition genes in extended pedigrees using SNP genotype assays.
Article in Annals of human genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed.
- GermlineJournal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023Article
- A role for the MEGF6 gene in predisposition to osteoporosis.Annals of human genetics · 2021Article
- Duo Shared Genomic Segment analysis identifies a genome-wide significant risk locus at 18q21.33 in myeloma pedigrees.Journal of translational genetics and genomics · 2021Article
- Shared genomic segment analysis in a large high-risk chronic lymphocytic leukemia pedigree implicatesJournal of translational genetics and genomics · 2021Article
- Genetic and Non-genetic Determinants of Cardiovascular Disease in South Asians.Current diabetes reviews · 2021Review
- Shared genomic segment analysis with equivalence testing.Genetic epidemiology · 2020Article
- Family Study Designs Informed by Tumor Heterogeneity and Multi-Cancer Pleiotropies: The Power of the Utah Population Database.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- A Nonsynonymous Variant in the GOLM1 Gene in Cutaneous Malignant Melanoma.Journal of the National Cancer Institute · 2018Article
- Reparameterization of PAM50 Expression Identifies Novel Breast Tumor Dimensions and Leads to Discovery of a Genome-Wide Significant Breast Cancer Locus atCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Article
- Relationship between Deleterious Variation, Genomic Autozygosity, and Disease Risk: Insights from The 1000 Genomes Project.American journal of human genetics · 2018Article
- Novel pedigree analysis implicates DNA repair and chromatin remodeling in multiple myeloma risk.PLoS genetics · 2018Article
- Weighted likelihood inference of genomic autozygosity patterns in dense genotype data.BMC genomics · 2017Article
- Analysis of Shared Haplotypes amongst Palauans Maps Loci for Psychotic Disorders to 4q28 and 5q23-q31.Molecular neuropsychiatry · 2017Article
- IBD Sharing between Africans, Neandertals, and Denisovans.Genome biology and evolution · 2016Article
- A Genealogical Look at Shared Ancestry on the X Chromosome.Genetics · 2016Article
- FamPipe: An Automatic Analysis Pipeline for Analyzing Sequencing Data in Families for Disease Studies.PLoS computational biology · 2016Article
- HaploShare: identification of extended haplotypes shared by cases and evaluation against controls.Genome biology · 2015Article
- Combinatorial Conflicting Homozygosity (CCH) analysis enables the rapid identification of shared genomic regions in the presence of multiple phenocopies.BMC genomics · 2015Article
- Pedigree-Free Descent-Based Gene Mapping from Population Samples.Human heredity · 2015Article
- Identifying bipolar disorder susceptibility loci in a densely affected pedigree.Molecular psychiatry · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We examine the utility of high density genotype assays for predisposition gene localization using extended pedigrees. Results for the distribution of the number and length of genomic segments shared identical by descent among relatives previously derived in the context of genomic mismatch scanning are reviewed in the context of dense single nucleotide polymorphism maps. We use long runs of loci at which cases share a common allele identically by state to localize hypothesized predisposition genes. The distribution of such runs under the hypothesis of no genetic effect is evaluated by simulation. Methods are illustrated by analysis of an extended prostate cancer pedigree previously reported to show significant linkage to chromosome 1p23. Our analysis establishes that runs of simple single locus statistics can be powerful, tractable and robust for finding DNA shared between relatives, and that extended pedigrees offer powerful designs for gene detection based on these statistics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.