ArticleJournal of anatomy2008
Phenotypic variability and craniofacial dysmorphology: increased shape variance in a mouse model for cleft lip.
Article in Journal of anatomy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed.
- Leveraging the genetics of human face shape boosts the discovery of orofacial cleft risk loci.medRxiv : the preprint server for health sciences · 2026Article
- Quantifying the relationship between cell proliferation and morphology during development of the face.Development (Cambridge, England) · 2025Article
- Using data-driven phenotyping to investigate the impact of sex on 3D human facial surface morphology.Journal of anatomy · 2023Article
- Morphometric analysis of the size-adjusted linear dimensions of the skull landmarks revealed craniofacial dysmorphology in Mid1-cKO mice.BMC genomics · 2023Article
- Disruption ofFrontiers in cell and developmental biology · 2023Article
- Article
- What's Shape Got to Do With It? Examining the Relationship Between Facial Shape and Orofacial Clefting.Frontiers in genetics · 2022Review
- Mouse embryo phenotyping using X-ray microCT.Frontiers in cell and developmental biology · 2022Review
- Symmetry and fluctuation of cell movements in neural crest-derived facial mesenchyme.Development (Cambridge, England) · 2021Article
- The Intersection of the Genetic Architectures of Orofacial Clefts and Normal Facial Variation.Frontiers in genetics · 2021Article
- Craniofacial Analysis May Indicate Co-Occurrence of Skeletal Malocclusions and Associated Risks in Development of Cleft Lip and Palate.Journal of developmental biology · 2020Article
- The developmental-genetics of canalization.Seminars in cell & developmental biology · 2019Review
- Developmental processes regulate craniofacial variation in disease and evolution.Genesis (New York, N.Y. : 2000) · 2019Review
- Quantifying three-dimensional morphology and RNA from individual embryos.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Article
- Postnatal Development of the Craniofacial Skeleton in Male C57BL/6J Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2016Article
- Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage.Disease models & mechanisms · 2015Article
- Morphometrics, 3D Imaging, and Craniofacial Development.Current topics in developmental biology · 2015Review
- Facial morphometrics of children with non-syndromic orofacial clefts in Tanzania.BMC oral health · 2014Article
- Surface landmark quantification of embryonic mouse craniofacial morphogenesis.BMC developmental biology · 2014Article
- Long-range enhancers regulating Myc expression are required for normal facial morphogenesis.Nature genetics · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cleft lip and palate (CL/P), as is true of many craniofacial malformations in humans, is etiologically complex and highly variable in expression. A/WySn mice are an intriguing model for human CL/P because they develop this dysmorphology with a variable expression pattern, incomplete penetrance and frequent unilateral expression on a homogeneous genetic background. The developmental basis for this variation in expression is unknown, but of great significance for understanding such expression patterns in humans. As a step towards this goal, this study used three-dimensional geometric morphometric and novel high throughput morphometric techniques based on three-dimensional computed microtomography of mouse embryos to analyze craniofacial shape variation during primary palate formation. Our analysis confirmed previous findings based on two-dimensional analyses that the midface in A/WySn embryos, and the maxillary prominence in particular, is relatively reduced in size and appears to be developmentally delayed. In addition, we find that shape variance is increased in A/WySn embryos during primary palate formation compared to both C57BL/6J mice and the F1 crosses between these strains. If the reduction in midfacial growth caused by the Wnt9b hypomorphic mutation pushes A/WySn mice closer on average to the threshold for cleft lip formation, the elevated shape variance may explain why some, but not all, embryos develop the dysmorphology in a genetically homogeneous inbred line of mice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.