ArticleJournal of neuroscience research2008
Modeling the neurovascular niche: murine strain differences mimic the range of responses to chronic hypoxia in the premature newborn.
Article in Journal of neuroscience research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Minocycline mitigates the effect of neonatal hypoxic insult on human brain organoids.Cell death & disease · 2019Article
- Strain-Related Differences in Mouse Neonatal Hypoxia-Ischemia.Developmental neuroscience · 2018Article
- Sex Steroids and Adult Neurogenesis in the Ventricular-Subventricular Zone.Frontiers in endocrinology · 2018Review
- The role of endothelial HIF-1 αin the response to sublethal hypoxia in C57BL/6 mouse pups.Laboratory investigation; a journal of technical methods and pathology · 2017Article
- Deferoxamine Preconditioning of Neural-Like Cells Derived from Human Wharton's Jelly Mesenchymal Stem Cells as a Strategy to Promote Their Tolerance and Therapeutic Potential: An In Vitro Study.Cellular and molecular neurobiology · 2016Article
- The role of different strain backgrounds in bacterial endotoxin-mediated sensitization to neonatal hypoxic-ischemic brain damage.Neuroscience · 2015Article
- Modulation of Sox10, HIF-1α, Survivin, and YAP by Minocycline in the Treatment of Neurodevelopmental Handicaps following Hypoxic Insult.The American journal of pathology · 2015Article
- Hypoxic preconditioning protection is eliminated in HIF-1α knockout mice subjected to neonatal hypoxia-ischemia.Pediatric research · 2014Article
- Electroacupuncture preconditioning reduces cerebral ischemic injury via BDNF and SDF-1α in mice.BMC complementary and alternative medicine · 2013Article
- Modeling the neurovascular niche: unbiased transcriptome analysis of the murine subventricular zone in response to hypoxic insult.PloS one · 2013Article
- CXCR7 silencing attenuates cell adaptive response to stromal cell derived factor 1α after hypoxia.PloS one · 2013Article
- Hypoxia in the regulation of neural stem cells.Cellular and molecular life sciences : CMLS · 2011Review
- Modeling premature brain injury and recovery.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2009Review
- Strain differences in behavioral and cellular responses to perinatal hypoxia and relationships to neural stem cell survival and self-renewal: Modeling the neurovascular niche.The American journal of pathology · 2009Article
- VEGF-A and Semaphorin3A: modulators of vascular sympathetic innervation.Developmental biology · 2009Article
- Characterization of RAGE, HMGB1, and S100beta in inflammation-induced preterm birth and fetal tissue injury.The American journal of pathology · 2009Article
- The cortical innate immune response increases local neuronal excitability leading to seizures.Brain : a journal of neurology · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Preterm birth results in significant cognitive and motor disabilities, but recent evidence suggests that there is variable recovery over time. One possibility that may explain this variable recovery entails variable neurogenic responses in the subventricular zone (SVZ) following the period of chronic hypoxia experienced by these neonates. In this report, we have characterized the responses to chronic hypoxia of two mouse strains that represent a wide range of susceptibility to chronic hypoxia. We determined that C57BL/6 pups and neural progenitor cells (NPCs) derived from them exhibit a blunted response to hypoxic insult compared with CD-1 pups and NPCs. Specifically, C57BL/6 pups and NPCs exhibited blunted in vivo and in vitro proliferative and increased apoptotic responses to hypoxic insult. Additionally, C57BL/6 NPCs exhibited lower baseline levels and hypoxia-induced levels of selected transcription factors, growth factors, and receptors (including HIF-1alpha, PHD2, BDNF, VEGF, SDF-1, TrkB, Nrp-1, CXCR4, and NO) that determine, in part, the responsiveness to chronic hypoxic insult compared with CD-1 pups and NPCs, providing insight into this important and timely problem in perinatology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.