ArticleMolecular medicine (Cambridge, Mass.)
Neuronal nitric oxide synthase contributes to the regulation of hematopoiesis.
Article in Molecular medicine (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Nitric oxide-dependent expansion of erythroid progenitors in a murine model of chronic psychological stress.Histochemistry and cell biology · 2020Article
- Nitric Oxide in the Control of theFrontiers in cell and developmental biology · 2020Article
- Review
- Regulation of long-term repopulating hematopoietic stem cells by EPCR/PAR1 signaling.Annals of the New York Academy of Sciences · 2016Review
- Endothelial progenitor cell dysfunction in myelodysplastic syndromes: possible contribution of a defective vascular niche to myelodysplasia.Neoplasia (New York, N.Y.) · 2015Article
- Deconvoluting the ontogeny of hematopoietic stem cells.Cellular and molecular life sciences : CMLS · 2014Review
- Biomechanical force in blood development: extrinsic physical cues drive pro-hematopoietic signaling.Differentiation; research in biological diversity · 2013Review
- Adult mesenchymal stem cells and the NO pathways.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Co-expression of endothelial and neuronal nitric oxide synthases in the developing vasculatures of the human fetal eye.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2012Article
- Changes in the Proteasome Pool during Malignant Transformation of Mouse Liver Cells.Acta naturae · 2010Article
- Article
- Nitrergic response to cyclophosphamide treatment in blood and bone marrow.The open biochemistry journal · 2008Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) signaling is important for the regulation of hematopoiesis. However, the role of individual NO synthase (NOS) isoforms is unclear. Our results indicate that the neuronal NOS isoform (nNOS) regulates hematopoiesis in vitro and in vivo. nNOS is expressed in adult bone marrow and fetal liver and is enriched in stromal cells. There is a strong correlation between expression of nNOS in a panel of stromal cell lines established from bone marrow and fetal liver and the ability of these cell lines to support hematopoietic stem cells; furthermore, NO donor can further increase this ability. The number of colonies generated in vitro from the bone marrow and spleen of nNOS-null mutants is increased relative to wild-type or inducible- or endothelial NOS knockout mice. These results describe a new role for nNOS beyond its action in the brain and muscle and suggest a model where nNOS, expressed in stromal cells, produces NO which acts as a paracrine regulator of hematopoietic stem cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.