ArticleJournal of hypertension2008
A cross-national study of the persistence of antihypertensive medication use in the elderly.
Article in Journal of hypertension, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Meta-analysis: impact of drug class on adherence to antihypertensives.Circulation · 2011Pooled it
- Trial
- Optimal P2YAmerican heart journal plus : cardiology research and practice · 2023Article
- Medication Adherence and Blood Pressure Control: A Scientific Statement From the American Heart Association.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Disparities by sex in P2YBMJ open · 2021Article
- Article
- Analysis of Adherence to Antihypertensive Drugs in Chinese Patients with Hypertension: A Retrospective Analysis Using the China Health Insurance Association Database.Patient preference and adherence · 2020Article
- Clinic-Based Strategies to Reach United States Million Hearts 2022 Blood Pressure Control Goals.Circulation. Cardiovascular quality and outcomes · 2019Article
- Conceptual Model of Medication Adherence in Older Adults with High Blood Pressure-An Integrative Review of the Literature.Current hypertension reviews · 2019Review
- Persistence with antihypertensives in uncomplicated treatment-naïve very elderly patients: a nationwide population-based study.BMC cardiovascular disorders · 2017Article
- Persistence profile to nucleos(t)ide analogue treatment for patients with chronic hepatitis B.European journal of hospital pharmacy : science and practice · 2016Article
- Persistence and compliance with newly initiated antihypertensive drug treatment in patients with chronic kidney disease.Patient preference and adherence · 2016Article
- Persistence with Antihypertensive Medications in Uncomplicated Treatment-Naïve Patients: Effects of Initial Therapeutic Classes.Journal of Korean medical science · 2015Article
- Discontinuation of anti-hypertensive drugs increases 11-year cardiovascular mortality risk in community-dwelling elderly (the Bambuí Cohort Study of Ageing).BMC public health · 2014Article
- Proportion and risk indicators of nonadherence to antihypertensive therapy: a meta-analysis.Patient preference and adherence · 2014Article
- Persistence to antihypertensive drug treatment in Swedish primary healthcare.European journal of clinical pharmacology · 2013Article
- Drug adherence and the incidence of coronary heart disease- and stroke-specific mortality among 218,047 patients newly prescribed an antihypertensive medication: a five-year cohort study.International journal of cardiology · 2013Observational
- Standardizing terminology and definitions of medication adherence and persistence in research employing electronic databases.Medical care · 2013Article
- Choice of initial antihypertensive drugs and persistence of drug use--a 4-year follow-up of 78,453 incident users.European journal of clinical pharmacology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionLittle is known about cross-national comparisons of the persistence of antihypertensive medication treatment, trends in persistence, and factors associated with persistence. The aim of this study was to describe and compare patterns of use of antihypertensive drugs in a population of elderly patients in the United States (Pennsylvania), Canada (British Columbia) and the Netherlands.
methodsA retrospective cohort study of Medicare enrollees in a state pharmacy assistance programme in Pennsylvania (USA), residents from British Columbia (Canada) and residents from the Netherlands registered in the PHARMO database was conducted. Each population included patients 65 years and older who were initiated on blood pressure-lowering treatment between 1 January 1998 and 31 December 2003 and who had continuous follow-up for at least 365 days. In these populations, the proportion of patients with at least 180 consecutive days without medication available (non-persistence) were identified as were predictors of non-persistence using Cox proportional hazards.
resultsA total of 9664 Medicare enrollees (USA), 25 377 residents from British Columbia and 24 603 residents from the Netherlands were evaluated. During the first year after the initiation of treatment, the percentage of patients with at least 180 days without medication was 23.3% in Pennsylvania, 23.4% in British Columbia and 24.0% in the Netherlands. After 6 years, these percentages increased to 41.1, 36.3 and 38.2%, respectively. Factors associated with non-persistence were different between the three countries.
conclusionDespite differences in factors associated with persistence, non-persistence patterns are strikingly similar in all three populations. This suggests that the problem of non-persistence transcends international boundaries.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.