ArticlePharmacoEconomics2008
Dynamic modelling of infectious diseases: an application to the economic evaluation of influenza vaccination.
Article in PharmacoEconomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Optimizing influenza prevention: a systematic review of the cost-effectiveness of pediatric vaccination programs and vaccine types.Frontiers in public health · 2025Pooled it
- Methods for Health Economic Evaluation of Vaccines and Immunization Decision Frameworks: A Consensus Framework from a European Vaccine Economics Community.PharmacoEconomics · 2016Pooled it
- An approximation of herd effect due to vaccinating children against seasonal influenza - a potential solution to the incorporation of indirect effects into static models.BMC infectious diseases · 2013Pooled it
- Estimated Burden of Influenza and Direct and Indirect Benefits of Influenza Vaccination.JAMA network open · 2025Article
- Cost-benefit analysis of the National Immunization Program in Spain.Human vaccines & immunotherapeutics · 2024Article
- Article
- Data-Related Challenges in Cost-Effectiveness Analyses of Vaccines.Applied health economics and health policy · 2022Article
- Simulation and forecasting models of COVID-19 taking into account spatio-temporal dynamic characteristics: A review.Frontiers in public health · 2022Review
- Article
- Economic Evaluations of New Antibiotics: The High Potential Value of Reducing Healthcare Transmission Through Decolonization.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- From trivalent to quadrivalent influenza vaccines: Public health and economic burden for different immunization strategies in Spain.PloS one · 2020Article
- Cost-consequence analysis of influenza vaccination among the staff of a large teaching hospital in Rome, Italy: A pilot study.PloS one · 2019Article
- Cost-utility analysis of antiviral use under pandemic influenza using a novel approach - linking pharmacology, epidemiology and heath economics.Epidemiology and infection · 2018Article
- Interdisciplinary pharmacometrics linking oseltamivir pharmacology, influenza epidemiology and health economics to inform antiviral use in pandemics.British journal of clinical pharmacology · 2017Article
- Direct and indirect effects of influenza vaccination.BMC infectious diseases · 2017Article
- Cost-effectiveness analysis of quadrivalent influenza vaccine in Spain.Human vaccines & immunotherapeutics · 2016Article
- Extending the elderly- and risk-group programme of vaccination against seasonal influenza in England and Wales: a cost-effectiveness study.BMC medicine · 2015Article
- Implementing an influenza vaccination programme for adults aged ≥65 years in Poland: a cost-effectiveness analysis.Clinical drug investigation · 2012Article
- Impact of program scale and indirect effects on the cost-effectiveness of vaccination programs.Medical decision making : an international journal of the Society for Medical Decision MakingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the economic efficiency of influenza vaccination using both dynamic and static modelling approaches.
settingThe Spanish National Health System. DESIGN AND
methodsWe modelled the progress of an influenza epidemic in Spain according to the epidemiological pattern of susceptible-->infective-->resistant, employing a non-linear system of ordinary differential equations that enables the measurement of epidemiological effects of an anti-influenza vaccination. We used a decision tree to represent the repercussion on healthcare resources use and on financial resources. The same analyses were conducted using a static approach, and the results were compared. Healthcare costs were valued in euro, year 2005 values.
resultsFor the base case, the impact of the healthcare intervention (vaccination) was not efficient from the perspective of the healthcare payer when using a static approach (return rate 0.28 per euro invested in vaccination). Nevertheless, it was efficient when employing a dynamic approach (return rate 1.22 per euro). Furthermore, a considerable freeing of healthcare resources would have been produced over the entire influenza season.
conclusionsThe indirect effect of vaccination on the non-vaccinated individuals (the 'herd immunity effect') can be greater than the direct effect on individuals vaccinated. This implies that the herd immunity effect needs to be taken into consideration in the economic evaluations of prophylactic measures employed against infectious diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.