ArticleEnvironmental health perspectives2007
Household exposure to pesticides and risk of childhood hematopoietic malignancies: The ESCALE study (SFCE).
Article in Environmental health perspectives, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Residential pesticides and childhood leukemia: a systematic review and meta-analysis.Environmental health perspectives · 2010Pooled it
- A systematic review and meta-analysis of childhood leukemia and parental occupational pesticide exposure.Environmental health perspectives · 2009Pooled it
- Are ARID5B and IKZF1 polymorphisms also associated with childhood acute myeloblastic leukemia: the ESCALE study (SFCE)?Leukemia · 2013Trial
- Cumulative Exposure to Unconventional Natural Gas Development and the Risk of Childhood Cancer: A Registry-Based Case-Control Study.International journal of environmental research and public health · 2025Article
- Evidence concerning parental exposure to pesticides and the occurrence of leukemia in offspring: a systematic review.Frontiers in pediatrics · 2025Review
- Interplay between Epstein-Barr virus infection and environmental xenobiotic exposure in cancer.Infectious agents and cancer · 2021Review
- Why We Will Continue to Lose Our Battle with Cancers If We Do Not Stop Their Triggers from Environmental Pollution.International journal of environmental research and public health · 2021Review
- Pesticide use and risk of Hodgkin lymphoma: results from the North American Pooled Project (NAPP).Cancer causes & control : CCC · 2020Article
- Maternal residential pesticide use and risk of childhood leukemia in Costa Rica.International journal of cancer · 2018Article
- A task-based assessment of parental occupational exposure to pesticides and childhood acute lymphoblastic leukemia.Environmental research · 2017Article
- Residential Exposure to Natural Background Radiation and Risk of Childhood Acute Leukemia in France, 1990-2009.Environmental health perspectives · 2017Article
- Acute myeloid leukaemia at an early age: Reviewing the interaction between pesticide exposure andEcancermedicalscience · 2017Review
- Passive exposure to agricultural pesticides and risk of childhood leukemia in an Italian community.International journal of hygiene and environmental health · 2016Article
- Article
- Home pesticide exposures and risk of childhood leukemia: Findings from the childhood leukemia international consortium.International journal of cancer · 2015Article
- Household pesticide exposure and the risk of childhood acute leukemia in Shanghai, China.Environmental science and pollution research international · 2015Article
- ARID5B, IKZF1 and non-genetic factors in the etiology of childhood acute lymphoblastic leukemia: the ESCALE study.PloS one · 2015Article
- Parental occupational pesticide exposure and the risk of childhood leukemia in the offspring: findings from the childhood leukemia international consortium.International journal of cancer · 2014Article
- Knowing the enemy: ant behavior and control in a pediatric hospital of Buenos Aires.SpringerPlus · 2014Article
- Exposure to herbicides in house dust and risk of childhood acute lymphoblastic leukemia.Journal of exposure science & environmental epidemiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 11 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe investigated the role of household exposure to pesticides in the etiology of childhood hematopoietic malignancies.
methodsThe national registry-based case-control study ESCALE (Etude sur les cancers de l'enfant) was carried out in France over the period 2003-2004. Population controls were frequency matched with the cases on age and sex. Maternal household use of pesticides during pregnancy and paternal use during pregnancy or childhood were reported by the mothers in a structured telephone questionnaire. Insecticides (used at home, on pets, or for garden crops), herbicides, and fungicides were distinguished. We estimated odds ratios (ORs) using unconditional regression models closely adjusting for age, sex, degree of urbanization, and type of housing (flat or house).
resultsWe included a total of 764 cases of acute leukemia (AL), 130 of Hodgkin lymphoma (HL), 166 of non-Hodgkin lymphoma (NHL), and 1,681 controls. Insecticide use during pregnancy was significantly associated with childhood AL [OR = 2.1; 95% confidence interval (CI), 1.7-2.5], both lymphoblastic and myeloblastic, NHL (OR = 1.8; 95% CI, 1.3-2.6), mainly for Burkitt lymphoma (OR = 2.7; 95% CI, 1.6-4.5), and mixed-cell HL (OR = 4.1; 95% CI, 1.4-11.8), but not nodular sclerosis HL (OR = 1.1; 95% CI, 0.6-1.9). Paternal household use of pesticides was also related to AL (OR = 1.5; 95% CI, 1.2-1.8) and NHL (OR = 1.7; 95% CI, 1.2-2.6); but for AL the relationships did not remain after adjustment for maternal pesticide use during pregnancy.
conclusionThe study findings strengthen the hypothesis that domestic use of pesticides may play a role in the etiology of childhood hematopoietic malignancies. The consistency of the findings with those of previous studies on AL raises the question of the advisability of preventing pesticide use by pregnant women.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.