ArticleEnvironmental health perspectives2007
Drinking water with uranium below the U.S. EPA water standard causes estrogen receptor-dependent responses in female mice.
Article in Environmental health perspectives, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Individual and combined antagonism of aryl hydrocarbon receptor (AhR) and estrogen receptors (ERs) offers distinct level of protection against Bisphenol A (BPA)-induced pancreatic islet cell toxicity in mice.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Protective effect of Moringa oleifera leaf ethanolic extract against uranyl acetate-induced testicular dysfunction in rats.Scientific reports · 2024Article
- Long-term environmental metal exposure is associated with hypomethylation of CpG sites in NFKB1 and other genes related to oncogenesis.Clinical epigenetics · 2023Article
- Juxtaposition of intensive agriculture, vulnerable aquifers, and mixed chemical/microbial exposures in private-well tapwater in northeast Iowa.The Science of the total environment · 2023Article
- A Novel Eco-Friendly and Highly Sensitive Solid Lead-Tin Microelectrode for Trace U(VI) Determination in Natural Water Samples.Sensors (Basel, Switzerland) · 2023Article
- Bottled water contaminant exposures and potential human effects.Environment international · 2023Article
- Tapwater Exposures, Effects Potential, and Residential Risk Management in Northern Plains Nations.ACS ES&T water · 2022Article
- A Novel Triphenylamine-Based Flavonoid Fluorescent Probe with High Selectivity for Uranyl in Acid and High Water Systems.Sensors (Basel, Switzerland) · 2022Article
- Disproportionate Impacts of Radiation Exposure on Women, Children, and Pregnancy: Taking Back our Narrative.Journal of the history of biology · 2021Article
- Arsenite and cadmium promote the development of mammary tumors.Carcinogenesis · 2020Article
- Mixed organic and inorganic tapwater exposures and potential effects in greater Chicago area, USA.The Science of the total environment · 2020Article
- Uranium in drinking water: a public health threat.Archives of toxicology · 2020Review
- Quantification of Elemental Contaminants in Unregulated Water across Western Navajo Nation.International journal of environmental research and public health · 2019Article
- Elevated serum chemokines are independently associated with both endometriosis and uranium exposure.Reproductive toxicology (Elmsford, N.Y.) · 2019Article
- Human exposure to uranium in South African gold mining areas using barber-based hair sampling.PloS one · 2019Article
- Reconnaissance of Mixed Organic and Inorganic Chemicals in Private and Public Supply Tapwaters at Selected Residential and Workplace Sites in the United States.Environmental science & technology · 2018Article
- Health Effects and Environmental Justice Concerns of Exposure to Uranium in Drinking Water.Current environmental health reports · 2016Review
- Birth outcomes and background exposures to select elements, the Longitudinal Investigation of Fertility and the Environment (LIFE).Environmental research · 2015Article
- Association of systemic lupus erythematosus with uranium exposure in a community living near a uranium-processing plant: a nested case-control study.Arthritis & rheumatology (Hoboken, N.J.) · 2014Article
- Effects of magnetized water on ovary, pre-implantation stage endometrial and fallopian tube epithelial cells in mice.Iranian journal of reproductive medicine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundThe deleterious impact of uranium on human health has been linked to its radioactive and heavy metal-chemical properties. Decades of research has defined the causal relationship between uranium mining/milling and onset of kidney and respiratory diseases 25 years later.
objectiveWe investigated the hypothesis that uranium, similar to other heavy metals such as cadmium, acts like estrogen.
methodsIn several experiments, we exposed intact, ovariectomized, or pregnant mice to depleted uranium in drinking water [ranging from 0.5 microg/L (0.001 microM) to 28 mg/L (120 microM).
resultsMice that drank uranium-containing water exhibited estrogenic responses including selective reduction of primary follicles, increased uterine weight, greater uterine luminal epithelial cell height, accelerated vaginal opening, and persistent presence of cornified vaginal cells. Coincident treatment with the antiestrogen ICI 182,780 blocked these responses to uranium or the synthetic estrogen diethylstilbestrol. In addition, mouse dams that drank uranium-containing water delivered grossly normal pups, but they had significantly fewer primordial follicles than pups whose dams drank control tap water.
conclusionsBecause of the decades of uranium mining/milling in the Colorado plateau in the Four Corners region of the American Southwest, the uranium concentration and the route of exposure used in these studies are environmentally relevant. Our data support the conclusion that uranium is an endocrine-disrupting chemical and populations exposed to environmental uranium should be followed for increased risk of fertility problems and reproductive cancers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.