Evidence map›Paper›PMID 18087293›Full record

ReviewNature reviews. Genetics2008

Research ethics and the challenge of whole-genome sequencing.

Amy L McGuire, Timothy Caulfield, Mildred K Cho

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02422511 (Genomic Sequencing for Childhood Risk and Newborn Illness), which is not on this map. Cited by 112 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02422511 nacompletednot on this mapstarted 2015, after this paper: background citation

Genomic Sequencing for Childhood Risk and Newborn Illness (The BabySeq Project)

TypeinterventionalSponsorBrigham and Women's HospitalRan2015 to 2021Enrolled1,205ConditionsHereditary Disease, Genetic Predisposition to DiseaseArmsGenomic sequencing, Family history report
3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  20. Retinitis Pigmentosa: Current Clinical Management and Emerging Therapies.International journal of molecular sciences · 2023
    Review

52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Amy L McGuireAmy L. McGuire is at the Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, Texas 77030, USA.
Timothy Caulfield
Mildred K Cho

Funding

Center for Integration of Research on Genetics and EthicsP50HG003389 · NHGRI · STANFORD UNIVERSITY · PI CHO, MILDRED K. · 2004 to 2014
$9.9M
The ethics of consent for the public release of potentially identifiable DNA dataR01HG004333 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI MCGUIRE, AMY L · 2007 to 2009
$1.1M
NHGRI NIH HHS 5P50HG003389NHGRI NIH HHS P50 HG003389NHGRI NIH HHS R01 HG004333NHGRI NIH HHS R01HG004333
6 · The paper itself

Abstract

The recent completion of the first two individual whole-genome sequences is a research milestone. As personal genome research advances, investigators and international research bodies must ensure ethical research conduct. We identify three major ethical considerations that have been implicated in whole-genome research: the return of research results to participants; the obligations, if any, that are owed to participants' relatives; and the future use of samples and data taken for whole-genome sequencing. Although the issues are not new, we discuss their implications for personal genomics and provide recommendations for appropriate management in the context of research involving individual whole-genome sequencing.

Indexed as

Ethics, ResearchGenome, HumanFamilyHealth Planning GuidelinesHumansMolecular Sequence DataPublic PolicyPublishingResearchResearch SubjectsSequence Analysis, DNAThird-Party Consent

Identifiers

PMID18087293
PMCPMC2225443

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.