ArticleMolecular and cellular biology2008
ARS2 is a conserved eukaryotic gene essential for early mammalian development.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 51 citations in OpenAlex.
- ARS2, a Cofactor of CBC, Promotes Meiotic Silencing by Unpaired DNA.Epigenomes · 2026Article
- Defining the roles of the Integrator, NEXT, and nuclear exosome complexes in Drosophila oogenesis.Cell reports · 2025Article
- An antisense intragenic lncRNA SEAIRa mediates transcriptional and epigenetic repression ofProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Oak stands along an elevation gradient have different molecular strategies for regulating bud phenology.BMC plant biology · 2023Article
- Du13 encodes a CPlant biotechnology journal · 2022Article
- Identification of Three Key Genes Associated with Hepatocellular Carcinoma Progression Based on Co-expression Analysis.Cell biochemistry and biophysics · 2022Article
- Cytoplasmic switch of ARS2 isoforms promotes nonsense-mediated mRNA decay and arsenic sensitivity.Nucleic acids research · 2022Article
- Mapping domains of ARS2 critical for its RNA decay capacity.Nucleic acids research · 2020Article
- ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages.Nature communications · 2020Article
- Improved hematopoietic differentiation of mouse embryonic stem cells through manipulation of the RNA binding protein ARS2.Stem cell research · 2020Article
- Article
- Knockdown of arsenic resistance protein 2 inhibits human glioblastoma cell proliferation through the MAPK/ERK pathway.Oncology reports · 2018Article
- Ars2 promotes cell proliferation and tumorigenicity in glioblastoma through regulating miR-6798-3p.Scientific reports · 2018Article
- Arabidopsis RNA processing factor SERRATE regulates the transcription of intronless genes.eLife · 2018Article
- The RNA binding protein Ars2 supports hematopoiesis at multiple levels.Experimental hematology · 2018Article
- Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.Nature communications · 2018Article
- Mechanisms of microRNA-mediated gene regulation in unicellular model algaBiotechnology for biofuels · 2018Review
- The role of TREX in gene expression and disease.The Biochemical journal · 2016Review
- 2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells.Archives of toxicology · 2016Article
- Mutagenesis of ARS2 Domains To Assess Possible Roles in Cell Cycle Progression and MicroRNA and Replication-Dependent Histone mRNA Biogenesis.Molecular and cellular biology · 2015Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Determining the functions of novel genes implicated in cell survival is directly relevant to our understanding of mammalian development and carcinogenesis. ARS2 is an evolutionarily conserved gene that confers arsenite resistance on arsenite-sensitive Chinese hamster ovary cells. Little is known regarding the function of ARS2 in mammals. We report that ARS2 is transcribed throughout embryonic development and is expressed ubiquitously in mouse and human tissues. The mouse ARS2 protein is predominantly localized to the nucleus, and this nuclear localization is ablated in ARS2-null embryos, which in turn die around the time of implantation. After 24 h of culture, ARS2-null blastocysts contained a significantly greater number of apoptotic cells than wild-type or heterozygous blastocysts. By 48 h of in vitro culture, null blastocysts invariably collapsed and failed to proliferate. These data indicate ARS2 is essential for early mammalian development and is likely involved in an essential cellular process. The analysis of data from several independent protein-protein interaction studies in mammals, combined with functional studies of its Arabidopsis ortholog, SERRATE, suggests that this essential process is related to RNA metabolism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.