ArticleNucleic acids research2008
The cucumovirus 2b gene drives selection of inter-viral recombinants affecting the crossover site, the acceptor RNA and the rate of selection.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 27 citations in OpenAlex.
- Generation and Retention of Defective RNA3 from Cucumber Mosaic Virus and Relevance of the 2b Protein to Generation of the Subviral RNA.The plant pathology journal · 2023Article
- Genome characterization and host range studies ofVirusdisease · 2021Article
- Genetic structure and molecular variability of Cucumber mosaic virus isolates in the United States.PloS one · 2014Article
- Mapping viral functional domains for genetic diversity in plants.Journal of virology · 2013Article
- Fixation of emerging interviral recombinants in cucumber mosaic virus populations.Journal of virology · 2013Article
- A novel virus genome discovered in an extreme environment suggests recombination between unrelated groups of RNA and DNA viruses.Biology direct · 2012Article
- RNA binding is more critical to the suppression of silencing function of Cucumber mosaic virus 2b protein than nuclear localization.RNA (New York, N.Y.) · 2012Article
- Structural basis for RNA-silencing suppression by Tomato aspermy virus protein 2b.EMBO reports · 2008Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA-RNA recombination is an important pathway in virus evolution and has been described for many viruses. However, the factors driving recombination or promoting the selection of recombinants are still unclear. Here, we show that the small movement protein (2b) was able to promote selection of RNA 1/2-RNA 3 recombinants within a chimeric virus having RNAs 1 and 2 from cucumber mosaic virus, and RNA 3 from the related tomato aspermy virus, along with heterologous 2b genes. The source of the 2b also determined the selection of the acceptor RNA and the crossover site, as well as affecting the rate of selection of the recombinant RNAs. The nature of the RNA 3 also influenced the selection of the recombinant RNAs. A 163-nt tandem repeat in RNA 3 significantly affected the rate of selection of the recombinant RNA, while a single nucleotide within the repeat affected the crossover site. The recombination occurred in a non-random manner, involved no intermediates and probably was generated via a copy-choice mechanism during (+) strand RNA synthesis.
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