ArticleNucleic acids research2008
Differentiation-dependent lysine 4 acetylation enhances MEF2C binding to DNA in skeletal muscle cells.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- The Diverse Roles of the MEF2 Transcription Factor Family in Tumor Progression and Emerging Therapeutic Opportunities.Biomedicines · 2026Review
- Myocyte Enhancer Factor 2A Plays a Central Role in the Regulatory Networks of Cellular Physiopathology.Aging and disease · 2023Review
- Transcriptomic and genomic studies classify NKL54 as a histone deacetylase inhibitor with indirect influence on MEF2-dependent transcription.Nucleic acids research · 2022Article
- Progress on the roles of MEF2C in neuropsychiatric diseases.Molecular brain · 2022Review
- Histone H3 N-terminal mimicry drives a novel network of methyl-effector interactions.The Biochemical journal · 2021Article
- Emerging roles for MEF2 in brain development and mental disorders.Current opinion in neurobiology · 2019Review
- Mechanotransduction, nuclear architecture and epigenetics in Emery Dreifuss Muscular Dystrophy: tous pour un, un pour tous.Nucleus (Austin, Tex.) · 2018Review
- Concise Review: Epigenetic Regulation of Myogenesis in Health and Disease.Stem cells translational medicine · 2016Review
- Review
- PAK1 and CtBP1 Regulate the Coupling of Neuronal Activity to Muscle Chromatin and Gene Expression.Molecular and cellular biology · 2015Article
- Phosphorylation-dependent degradation of MEF2C contributes to regulate G2/M transition.Cell cycle (Georgetown, Tex.) · 2015Article
- Distinct functions of alternatively spliced isoforms encoded by zebrafish mef2ca and mef2cb.Biochimica et biophysica acta · 2014Article
- Suppression of the GLUT4 adaptive response to exercise in fructose-fed rats.American journal of physiology. Endocrinology and metabolism · 2014Article
- Modulation of lysine methylation in myocyte enhancer factor 2 during skeletal muscle cell differentiation.Nucleic acids research · 2014Article
- Molecular cloning and in silico analysis of the duck (Anas platyrhynchos) MEF2A gene cDNA and its expression profile in muscle tissues during fetal development.Genetics and molecular biology · 2012Article
- Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly.Nucleic acids research · 2011Article
- Computational integration of homolog and pathway gene module expression reveals general stemness signatures.PloS one · 2011Article
- Proline isomerase Pin1 represses terminal differentiation and myocyte enhancer factor 2C function in skeletal muscle cells.The Journal of biological chemistry · 2010Article
- Sumoylation and regulation of cardiac gene expression.Circulation research · 2010Review
- Transcriptional induction of MMP-10 by TGF-beta, mediated by activation of MEF2A and downregulation of class IIa HDACs.Oncogene · 2010Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Myocyte enhancer factor 2 (MEF2) proteins play a key role in promoting the expression of muscle-specific genes in differentiated muscle cells. MEF2 activity is regulated by the association with several transcriptional co-factors and by post-translational modifications. In the present report, we provide evidence for a novel regulatory mechanism of MEF2C activity, which occurs at the onset of skeletal muscle differentiation and is based on Lys4 acetylation. This covalent modification results in the enhancement of MEF2C binding to DNA and chromatin. In particular, we report that the kinetic parameters of MEF2/DNA association change substantially upon induction of differentiation to give a more stable complex and that this effect is mediated by Lys4 acetylation. We also show that Lys4 acetylation plays a prominent role in the p300-dependent activation of MEF2C.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.