Evidence map›Paper›PMID 18086397›Full record

ArticleJournal of critical care2007

Intensive care unit exposures for long-term outcomes research: development and description of exposures for 150 patients with acute lung injury.

Dale M Needham, Weiwei Wang, Sanjay V Desai, Pedro A Mendez-Tellez, Cheryl R Dennison, Jonathan Sevransky, Carl Shanholtz, Nancy Ciesla, Kim Spillman, Peter J Pronovost

3 registry-linked trialsAbstract read
In one paragraph

Article in Journal of critical care, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00300248 completednot on this map

The Improving Care of Acute Lung Injury Patients (ICAP) Study

TypeobservationalSponsorJohns Hopkins UniversityRan2004 to 2012Enrolled520ConditionsRespiratory Distress Syndrome, Adult
NCT01690910 naterminatednot on this mapstarted 2012, after this paper: background citation

Effects of Mobility Devices on Nursing Compliance With Mobility Protocols.

TypeinterventionalSponsorTrinity Health MichiganRan2012 to 2013Enrolled3ConditionsMobility LimitationsArmsRifton Gait Trainer, Front Wheeled Walker
NCT03413189 unknown statusnot on this mapstarted 2018, after this paper: background citation

PREDICTABLE: The Effect of Exercise Dosage on Physical Function, Cognition and Disability Following Critical Illness

TypeobservationalSponsorAustralian and New Zealand Intensive Care Research CentreRan2018 to 2023Enrolled40ConditionsCritical IllnessArmsReview of medical records, Assessment of physical and cognitive function, Interview of patients, carers and/or family members
3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
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  11. Review
  12. Occupational therapy for patients with acute lung injury: factors associated with time to first intervention in the intensive care unit.The American journal of occupational therapy : official publication of the American Occupational Therapy Association
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dale M NeedhamDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA. dale.needham@jhmi.edu
Weiwei Wang
Sanjay V Desai
Pedro A Mendez-Tellez
Cheryl R Dennison
Jonathan Sevransky
Carl Shanholtz
Nancy Ciesla
Kim Spillman
Peter J Pronovost

Funding

VENTILATOR ASSOCIATED LUNG INJURY: MOLECULAR APPROACHESP50HL073994 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI DIETTE, GREGORY B · 2003 to 2007
$21.3M
Protocol Driven Hemodynamic Support in Septic ShockK23GM071399 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI SEVRANSKY, JONATHAN E · 2005 to 2009
$671k
Improving Care in HF Patients through Decision SupportK23NR009193 · NINR · JOHNS HOPKINS UNIVERSITY · PI DENNISON, CHERYL · 2005 to 2007
$403k
NHLBI NIH HHS P50 HL073994NIGMS NIH HHS K23 GM071399NINR NIH HHS K23 NR009193
6 · The paper itself

Abstract

purposeLong-term follow-up studies in critical care have described survivors' outcomes, but provided less insight into the patient/disease characteristics and intensive care therapies ("exposures") associated with these outcomes. Such insights are essential for improving patients' long-term outcomes. This report describes the development of a strategy for comprehensively measuring relevant exposures for long-term outcomes research, and presents empiric results from its implementation. MATERIALS AND

methodsA multistep, iterative process was used to develop the exposures strategy. First, a comprehensive list of potential exposures was generated and subsequently reduced based on feasibility, redundancy, and relevance criteria. Next, data abstraction methods were designed and tested. Finally, the strategy was implemented in 150 patients with acute lung injury with iterative refinement.

resultsThe strategy resulted in the development of more than 60 unique exposures requiring less than 45 minutes per patient-day for data collection. Most exposures had minimal missing data and adequate reliability. These data revealed that evidence-based practices including lower tidal volume ventilation, spontaneous breathing trials, sedation interruption, adequate nutrition, and blood glucose of less than 6.1 mmol/L (110 mg/dL) occurred in only 23% to 50% of assessments.

conclusionsUsing a multistep, iterative process, a comprehensive and feasible exposure measurement strategy for long-term outcomes research was successfully developed and implemented.

Indexed as

Epidemiologic MethodsIntensive Care UnitsResearch DesignAdultAgedBaltimoreCohort StudiesData CollectionFemaleHealth StatusHumansMaleMiddle AgedOutcome Assessment, Health CareProspective StudiesQuality of Life

Identifiers

PMID18086397
PMCPMC3678945

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.