Trial reportJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2008
Regulation of bone turnover by sex steroids in men.
Trial report in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Trial
- Regulation of circulating sclerostin levels by sex steroids in women and in men.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Trial
- Effects of estrogen and testosterone on resting energy expenditure in older men.Obesity (Silver Spring, Md.) · 2010Trial
- Effects of parathyroid hormone treatment on circulating sclerostin levels in postmenopausal women.The Journal of clinical endocrinology and metabolism · 2010Trial
- Serum A20 level is associated with bone mineral density in male patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2025Article
- Musculoskeletal and body composition response to high-dose testosterone with finasteride after chronic incomplete spinal cord injury-a randomized, double-blind, and placebo-controlled pilot study.Frontiers in neurology · 2024Article
- Links between arterial stiffness and bone mineral density in middle-aged and elderly Chinese individuals: a cross-sectional study.BMJ open · 2019Observational
- Increase in Osteocalcin Following Testosterone Therapy in Men With Type 2 Diabetes and Subnormal Free Testosterone.Journal of the Endocrine Society · 2019Article
- Extragonadal FSHR Expression and Function-Is It Real?Frontiers in endocrinology · 2019Review
- Bone Mineral Density Is Negatively Associated With Arterial Stiffness in Men With Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- Battle of the sex steroids in the male skeleton: and the winner is....The Journal of clinical investigation · 2016Article
- Influence of aromatase inhibition on the bone-protective effects of testosterone.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- Sclerostin serum levels in prostate cancer patients and their relationship with sex steroids.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
- Article
- Aging and bone loss: new insights for the clinician.Therapeutic advances in musculoskeletal disease · 2012Article
- Reproductive hormones and bone.Current osteoporosis reports · 2010Review
- Physiology of bone loss.Radiologic clinics of North America · 2010Review
- Pathogenesis of Osteoporosis.Translational endocrinology & metabolism · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
introductionThe mechanism(s) by which sex steroids regulate bone turnover in humans are unclear, and recent studies have suggested that follicle-stimulating hormone (FSH) may play an important role in regulating bone resorption. MATERIALS AND
methodsFifty-nine men (median age, 69 yr) underwent suppression of sex steroids using a gonadotropin-releasing hormone (GnRH) agonist and aromatase blocker and were replaced with testosterone (T; 5 mg/d) and estradiol (E; 37.5 microg/d). After assessment of bone resorption markers (serum C-terminal telopeptide of type I collagen [CTX] and TRACP5b), they were randomized to sex steroid deficiency (-T, -E), E alone (-T, +E), T alone (+T, -E), or both (+T, +E) and restudied 3 wk later. Bone marrow aspirates were obtained to isolate osteoblastic, T, and monocytic cells using magnetic-activated cell sorting.
resultsSerum CTX and TRACP5b increased significantly (by 71% and 15%, p < 0.01 and < 0.001, respectively) in the -T, -E group, and these increases occurred despite a 60% suppression of serum FSH levels (p < 0.001) caused by the GnRH agonist. There were significant E (but not T) effects on preventing increases in serum CTx and TRACP levels. There was a nonsignificant trend (p = 0.122) for E to suppress RANKL mRNA levels in bone marrow osteoblastic cells. Changes in mRNA levels for other cytokines (TNF-alpha, interleukin (IL)-1alpha, IL-1beta, IL-1ra, IFN-gamma) in bone marrow cells were not significant.
conclusionsE has greater suppressive effects on bone resorption than T, and increased bone resorption after sex steroid deficiency can occur independently of changes in FSH secretion. E effects on bone resorption may be mediated by regulation of RANKL production by osteoblastic cells, although further studies using more highly purified cells may reduce the variability of the mRNA measurements and allow for clearer definition of the mediators of sex steroid action in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.