ArticlePLoS pathogens2007
A cellular basis for Wolbachia recruitment to the host germline.
Article in PLoS pathogens, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
86 citing papers in PubMed, 156 citations in OpenAlex.
- Non-Canonical, Somatic-Dependent Vertical Transmission of Wolbachia in an Aphid.Environmental microbiology reports · 2026Article
- Fexinidazole and Corallopyronin A target Wolbachia-infected sheath cells present in filarial nematodes.PLoS pathogens · 2025Article
- Article
- The Plasmodium transmission-blocking symbiont, Microsporidia MB, is vertically transmitted through Anopheles arabiensis germline stem cells.PLoS pathogens · 2024Article
- Describing endosymbiont-host interactions within the parasitism-mutualism continuum.Ecology and evolution · 2024Article
- Mixed Wolbachia infections resolve rapidly during in vitro evolution.PLoS pathogens · 2024Article
- Comparative analysis of Wolbachia maternal transmission and localization in host ovaries.Communications biology · 2024Article
- Comparative analysis ofbioRxiv : the preprint server for biology · 2024Article
- MixedbioRxiv : the preprint server for biology · 2024Article
- A Light in the Dark: Uncovering Wolbachia-Host Interactions Using Fluorescence Imaging.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Article
- Cross-validation of chemical and genetic disruption approaches to inform host cellular effects onFrontiers in microbiology · 2024Article
- The cellular lives of Wolbachia.Nature reviews. Microbiology · 2023Review
- Wolbachia endosymbionts manipulate the self-renewal and differentiation of germline stem cells to reinforce fertility of their fruit fly host.PLoS biology · 2023Article
- Distinct Wolbachia localization patterns in oocytes of diverse host species reveal multiple strategies of maternal transmission.Genetics · 2023Article
- Article
- A highly divergentProceedings. Biological sciences · 2022Article
- Cross-tissue and generation predictability of relative Wolbachia densities in the mosquito Aedes aegypti.Parasites & vectors · 2022Article
- Temperature effects on cellular host-microbe interactions explain continent-wide endosymbiont prevalence.Current biology : CB · 2022Article
- Positive Selection and Horizontal Gene Transfer in the Genome of a Male-Killing Wolbachia.Molecular biology and evolution · 2022Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Wolbachia are among the most widespread intracellular bacteria, carried by thousands of metazoan species. The success of Wolbachia is due to efficient vertical transmission by the host maternal germline. Some Wolbachia strains concentrate at the posterior of host oocytes, which promotes Wolbachia incorporation into posterior germ cells during embryogenesis. The molecular basis for this localization strategy is unknown. Here we report that the wMel Wolbachia strain relies upon a two-step mechanism for its posterior localization in oogenesis. The microtubule motor protein kinesin-1 transports wMel toward the oocyte posterior, then pole plasm mediates wMel anchorage to the posterior cortex. Trans-infection tests demonstrate that factors intrinsic to Wolbachia are responsible for directing posterior Wolbachia localization in oogenesis. These findings indicate that Wolbachia can direct the cellular machinery of host oocytes to promote germline-based bacterial transmission. This study also suggests parallels between Wolbachia localization mechanisms and those used by other intracellular pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.