ArticleMedical molecular morphology2007
Expression pattern of p63 in oral epithelial lesions and submucous fibrosis associated with betel-quid chewing in Sri Lanka.
Article in Medical molecular morphology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 18 citations in OpenAlex.
- Oral submucous fibrosis: pathogenesis and therapeutic approaches.International journal of oral science · 2025Review
- Single-cell and spatial dissection of precancerous lesions underlying the initiation process of oral squamous cell carcinoma.Cell discovery · 2023Article
- Collagen deposition correlates with loss of E-cadherin and increased p63 expression in dysplastic conditions of oral submucous fibrosis.Medical molecular morphology · 2022Article
- Can immunohistochemistry serve as an alternative to subjective histopathological diagnosis of oral epithelial dysplasia?Biomarkers in cancer · 2013Review
- Expression of p63 in potentially malignant and malignant oral lesions.Journal of oral biology and craniofacial researchArticle
- Expression of p63 and Proliferating Cell Nuclear Antigen in Oral Submucous Fibrosis.Journal of International Society of Preventive & Community DentistryArticle
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
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Abstract
Betel-quid chewing, which is closely related to the high incidence of oral cancer, is prevalent in Sri Lanka. p63 has a remarkable structural similarity to p53, suggesting an aberrant expression in oral cancer. Using anti-p63 antibody and immunohistochemistry, the present study investigated the expression pattern of p63 in oral epithelial lesions, including different types of squamous cell carcinoma (SCC), different grades of epithelial dysplasia, and submucosal fibrosis associated with betel-quid chewing. Nuclear immunoreactivity for p63 was detected in all the cases, including normal oral epithelium and epithelial lesions. In normal oral epithelium, nuclear positivity for p63 was observed in some of the basal cell layers and focally in the parabasal layer. Nuclear positivity increased in the epithelial lesions. The percentage of positive nuclei in the epithelial lesions was significantly higher than in normal epithelium (P < 0.01) and was also significantly higher in oral submucosal fibrosis than in epithelial dysplasia (P < 0.05). The results indicate that the overexpression of p63 in oral precancerous lesions and SCC in betel-quid chewers in Sri Lanka may be a useful marker for oral precancerous lesions.
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