Evidence map›Paper›PMID 18085375›Full record

ReviewMedical molecular morphology2007

Role of beta-defensins in oral epithelial health and disease.

Yoshihiro Abiko, Masto Saitoh, Michiko Nishimura, Mami Yamazaki, Daisuke Sawamura, Tohru Kaku

Abstract readReview
PubMed Publisher
In one paragraph

Review in Medical molecular morphology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 91 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Immune Dysfunction in Medication-Related Osteonecrosis of the Jaw.International journal of molecular sciences · 2023
    Review
  5. Chronic Kidney Disease and Periodontitis Interplay-A Narrative Review.International journal of environmental research and public health · 2023
    Review
  6. Article
  7. Review
  8. Oral Cavity andPathogens (Basel, Switzerland) · 2022
    Review
  9. Review
  10. Article
  11. Review
  12. Cells · 2019
    Article
  13. Article
  14. Interleukin-17 in Antifungal Immunity.Pathogens (Basel, Switzerland) · 2019
    Review
  15. Review
  16. Roles of Oral Infections in the Pathomechanism of Atherosclerosis.International journal of molecular sciences · 2018
    Review
  17. β-Defensin-2 is overexpressed in human vocal cord polyps.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017
    Article
  18. Oral antimicrobial peptides: Types and role in the oral cavity.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2016
    Review
  19. Oncogenic relevant defensins: expression pattern and proliferation characteristics of human tumor cell lines.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yoshihiro AbikoDepartment of Dental Science, Division of Oral Medicine and Pathology, Institute of Personalized Medical Science, Health Sciences University of Hokkaido, 2-5 Ainosato, Kita-ku, Sapporo, Hokkaido, Japan. yoshi-ab@hoku-iryo-u.ac.jp
Masto Saitoh
Michiko Nishimura
Mami Yamazaki
Daisuke Sawamura
Tohru Kaku
Health Sciences University of Hokkaido · JPHirosaki University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The oral epithelium functions as a mechanical and protective barrier to resist bacterial infection. beta-Defensins are a group of antimicrobial peptides mainly produced by epithelial cells of many organs including skin, lung, kidney, pancreas, uterus, eye, and nasal and oral mucosa. This review focuses on beta-defensins (BDs) in oral epithelia and discusses their importance in oral epithelial health and disease. BDs exhibit antimicrobial activity against oral microbes including periodontitis-related bacteria, Candida, and papilloma virus. Alterative expression of BDs was observed in oral epithelial diseases, including oral inflammatory lesions with and without microbial infection and oral cancer. BDs may be useful in the treatment of oral infectious diseases, ulcerative lesions, and cancer. BDs play an important role in protection against oral microbes and may be used in clinical applications.

Indexed as

DiseaseHealthAnimalsbeta-DefensinsGene Expression RegulationHumansMouth MucosaMouth Neoplasmsbeta-Defensins

Identifiers

PMID18085375
OpenAlexW1998197722

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.