Trial reportOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2008
Effect of dehydroepiandrosterone supplementation on bone mineral density, bone markers, and body composition in older adults: the DAWN trial.
Trial report in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00664053 (Effects of DHEA/Exercise on Bone, Muscle and Balance), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of DHEA/Exercise on Bone, Muscle and Balance
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- Clinical review: The benefits and harms of systemic dehydroepiandrosterone (DHEA) in postmenopausal women with normal adrenal function: a systematic review and meta-analysis.The Journal of clinical endocrinology and metabolism · 2014Pooled it
- Effects of short-term DHEA intake on hormonal responses in young recreationally trained athletes: modulation by gender.Endocrine · 2018Trial
- The effect of gonadal and adrenal steroid therapy on skeletal health in adolescents and young women with anorexia nervosa.Metabolism: clinical and experimental · 2012Trial
- Oral dehydroepiandrosterone replacement in older adults: effects on central adiposity, glucose metabolism and blood lipids.Clinical endocrinology · 2011Trial
- Dehydroepiandrosterone replacement therapy in older adults: 1- and 2-y effects on bone.The American journal of clinical nutrition · 2009Trial
- Increases in bone mineral density in response to oral dehydroepiandrosterone replacement in older adults appear to be mediated by serum estrogens.The Journal of clinical endocrinology and metabolism · 2008Trial
- Effects of dehydroepiandrosterone supplementation on cognitive function and quality of life: the DHEA and Well-Ness (DAWN) Trial.Journal of the American Geriatrics Society · 2008Trial
- Imbalances in adrenal hormones and their effects on bone metabolism.Endocrine journal · 2025Review
- Article
- Should Dehydroepiandrosterone Be Administered to Women?The Journal of clinical endocrinology and metabolism · 2022Review
- Non-invasive methods for the assessment of biomarkers and their correlation with radiographic maturity indicators - a scoping review.Progress in orthodontics · 2021Article
- In vitro and in vivo tenocyte-protective effectiveness of dehydroepiandrosterone against high glucose-induced oxidative stress.BMC musculoskeletal disorders · 2021Article
- Sex-specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials.Clinical endocrinology · 2019Article
- Dehydroepiandrosterone: a potential therapeutic agent in the treatment and rehabilitation of the traumatically injured patient.Burns & trauma · 2019Review
- Central intracrine DHEA synthesis in ageing-related neuroinflammation and neurodegeneration: therapeutic potential?Journal of neuroinflammation · 2018Review
- Sex steroid actions in male bone.Endocrine reviews · 2014Review
- Off-label use of hormones as an antiaging strategy: a review.Clinical interventions in aging · 2014Review
- Multiple hormonal dysregulation as determinant of low physical performance and mobility in older persons.Current pharmaceutical design · 2014Review
- Testosterone increases circulating dehydroepiandrosterone sulfate levels in the male rhesus macaque.Frontiers in endocrinology · 2014Article
- Osteoporosis in men.Nature reviews. Endocrinology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledWe present results of a randomized, placebo-controlled trial to examine the effect of 50 mg daily oral DHEA supplementation for one year on bone mineral density (BMD), bone metabolism and body composition in 225 healthy adults aged 55 to 85 years.
introductionDehydroepiandrosterone (DHEA) levels decline dramatically with age, concurrent with the onset of osteoporosis, suggesting a role for DHEA supplementation in preventing age-related bone loss.
methodsWe conducted a randomized, placebo-controlled trial to examine the effect of 50 mg daily oral DHEA supplementation for one year on bone mineral density (BMD), bone metabolism and body composition in 225 healthy adults aged 55 to 85 years.
resultsDHEA treatment increased serum DHEA and DHEA sulfate levels to concentrations seen in young adults. Testosterone, estradiol and insulin-like growth factor (IGF-1) levels increased in women (all p < 0.001), but not men, receiving DHEA. Serum C-terminal telopeptide of type-1 collagen levels decreased in women (p = 0.03), but not men, whereas bone-specific alkaline phosphatase levels were not significantly altered in either sex. After 12 months, there was a positive effect of DHEA on lumbar spine BMD in women (p = 0.03), but no effect was observed for hip, femoral neck or total body BMD, and no significant changes were observed at any site among men. Body composition was not affected by DHEA treatment in either sex.
conclusionAmong older healthy adults, daily administration of 50 mg of DHEA has a modest and selective beneficial effect on BMD and bone resorption in women, but provides no bone benefit for men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.