ArticleAdvances in space research : the official journal of the Committee on Space Research (COSPAR)2007
Comparative analysis of Drosophila melanogaster and Caenorhabditis elegans gene expression experiments in the European Soyuz flights to the International Space Station.
Article in Advances in space research : the official journal of the Committee on Space Research (COSPAR), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Hypergravity, Microgravity, and Animal Research.Methods in molecular biology (Clifton, N.J.) · 2026Review
- Review
- Space omics research in Europe: Contributions, geographical distribution and ESA member state funding schemes.iScience · 2022Review
- Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight.International journal of molecular sciences · 2021Article
- The gymnastics of epigenomics in rice.Plant cell reports · 2018Review
- Effect of spaceflight on the circadian rhythm, lifespan and gene expression of Drosophila melanogaster.PloS one · 2015Article
- Evaluation of the Fluids Mixing Enclosure System for Life Science Experiments During a CommercialAdvances in space research : the official journal of the Committee on Space Research (COSPAR) · 2013Article
- Remote automated multi-generational growth and observation of an animal in low Earth orbit.Journal of the Royal Society, Interface · 2012Article
- Spaceflight transcriptomes: unique responses to a novel environment.Astrobiology · 2012Article
- Review of the results from the International C. elegans first experiment (ICE-FIRST).Advances in space research : the official journal of the Committee on Space Research (COSPAR) · 2009Article
- Description of International Caenorhabditis elegans Experiment first flight (ICE-FIRST).Advances in space research : the official journal of the Committee on Space Research (COSPAR) · 2008Article
- Genomic response of the nematode Caenorhabditis elegans to spaceflight.Advances in space research : the official journal of the Committee on Space Research (COSPAR) · 2008Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The European Soyuz missions have been one of the main routes for conducting scientific experiments onboard the International Space Station, which is currently in the construction phase. A relatively large number of life and physical sciences experiments as well as technology demonstrations have been carried out during these missions. Included among these experiments are the Gene experiment during the Spanish "Cervantes" Soyuz mission and the ICE-1st experiment during the Dutch "Delta" mission. In both experiments, full genome microarray analyses were carried out on RNA extracted from whole animals recovered from the flight. These experiments indicated relatively large scale changes in gene expression levels in response to spaceflight for two popular model systems, Drosophila melanogaster (Gene) and Caenorabditis elegans (ICE-1st). Here we report a comparative analysis of results from these two experiments. Finding orthologous genes between the fruit fly and the nematode was far from straightforward, reducing the number of genes that we could compare to roughly 20% of the full comparative genome. Within this sub-set of the data (2286 genes), only six genes were found to display identical changes between species (decreased) while 1809 genes displayed no change in either species. Future experiments using ground simulation techniques will allow producing a better, more comprehensive picture of the putative set of genes affected in multicellular organisms by changes in gravity and getting a deeper understanding of how animals respond and adapt to spaceflight.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.