Evidence map›Paper›PMID 18084311›Full record

ArticleBritish journal of pharmacology2008

Sildenafil reduces alcohol-induced gastric damage: just say 'NO'.

R Duffin, C A Shaw, A G Rossi

Erratum issuedOpen access · greenAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 14 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

R DuffinMRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
C A Shaw
A G Rossi
The Queen's Medical Research Institute · GBUniversity of Edinburgh · GB

Funding

Medical Research Council G0601481
6 · The paper itself

Abstract

Although sildenafil (Viagra) and other phosphodiesterase V (PDE V) inhibitors are increasingly recognized for their use in the treatment of male erectile dysfunction and perhaps more recently pulmonary artery hypertension, less is known of their potential beneficial effects in other situations. Medeiros et al., in the current issue of the British Journal of Pharmacology, report that sildenafil dramatically reduces alcohol-induced gastric damage in rats. The authors provide convincing evidence that such protection not only occurs via the nitric oxide (NO)/cGMP pathway, but also involves regulation of ATP-sensitive potassium channels. Therefore, in addition to exerting anti-impotence efficacy, PDE V inhibitors may provide significant beneficial effects from mucosal injury induced by alcohol.

Indexed as

AnimalsArginineCyclic GMPCyclic Nucleotide Phosphodiesterases, Type 5Disease Models, AnimalEthanolGastric MucosaGlutathioneGuanylate CyclaseHemoglobinsKATP ChannelsNitric OxideNitric Oxide SynthasePeptic Ulcer HemorrhagePhosphodiesterase 5 InhibitorsPhosphodiesterase InhibitorsArginineCyclic GMPCyclic Nucleotide Phosphodiesterases, Type 5EthanolGlutathioneGuanylate CyclaseHemoglobinsKATP ChannelsNitric OxideNitric Oxide SynthasePhosphodiesterase 5 InhibitorsPhosphodiesterase InhibitorsPiperazinesPurinesSildenafil CitrateSulfones

Identifiers

PMID18084311
PMCPMC2259209
OpenAlexW2070220076

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.