ArticleEMBO reports2008
The Drosophila NURF remodelling and the ATAC histone acetylase complexes functionally interact and are required for global chromosome organization.
Article in EMBO reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Growth phase diets diminish histone acetyltransferase Gcn5 function and shorten lifespan of Drosophila males.EMBO reports · 2025Article
- NURF301 contributes to gypsy chromatin insulator-mediated nuclear organization.Nucleic acids research · 2022Article
- KAT2A complexes ATAC and SAGA play unique roles in cell maintenance and identity in hematopoiesis and leukemia.Blood advances · 2022Article
- Review
- Protein and Genetic Composition of Four Chromatin Types inCurrent genomics · 2017Article
- Chromatin binding of Gcn5 in Drosophila is largely mediated by CP190.Nucleic acids research · 2017Article
- Dosage Compensation and the Distribution of Sex-Biased Gene Expression in Drosophila: Considerations and Genomic Constraints.Journal of molecular evolution · 2016Article
- BPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis.Nature communications · 2016Article
- Dependence of the sperm/oocyte decision on the nucleosome remodeling factor complex was acquired during recent Caenorhabditis briggsae evolution.Molecular biology and evolution · 2014Article
- Chromatin remodelers fine-tune H3K36me-directed deacetylation of neighbor nucleosomes by Rpd3S.Molecular cell · 2013Article
- Distinct contributions of MSL complex subunits to the transcriptional enhancement responsible for dosage compensation in Drosophila.Nucleic acids research · 2012Article
- ATAC-king the complexity of SAGA during evolution.Genes & development · 2012Review
- Protein composition of interband regions in polytene and cell line chromosomes of Drosophila melanogaster.BMC genomics · 2011Article
- The nucleosome remodeling factor.FEBS letters · 2011Review
- TbISWI regulates multiple polymerase I (Pol I)-transcribed loci and is present at Pol II transcription boundaries in Trypanosoma brucei.Eukaryotic cell · 2011Article
- The ISWI chromatin remodeler organizes the hsrω ncRNA-containing omega speckle nuclear compartments.PLoS genetics · 2011Article
- Identical functional organization of nonpolytene and polytene chromosomes in Drosophila melanogaster.PloS one · 2011Article
- Genes of the ecdysone biosynthesis pathway are regulated by the dATAC histone acetyltransferase complex in Drosophila.Molecular and cellular biology · 2010Article
- The metazoan ATAC and SAGA coactivator HAT complexes regulate different sets of inducible target genes.Cellular and molecular life sciences : CMLS · 2010Article
- The structure-function link of compensated chromatin in Drosophila.Current opinion in genetics & development · 2009Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drosophila Gcn5 is the catalytic subunit of the SAGA and ATAC histone acetylase complexes. Here, we show that mutations in Gcn5 and the ATAC component Ada2a induce a decondensation of the male X chromosome, similar to that induced by mutations in the Iswi and Nurf301 subunits of the NURF nucleosome remodelling complex. Genetic studies as well as transcript profiling analysis indicate that ATAC and NURF regulate overlapping sets of target genes during development. In addition, we find that Ada2a chromosome binding and histone H4-Lys12 acetylation are compromised in Iswi and Nurf301 mutants. Our results strongly suggest that NURF is required for ATAC to access the chromatin and to regulate global chromosome organization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.