ArticleActa crystallographica. Section F, Structural biology and crystallization communications2007
Structure of Bacillus subtilis superoxide dismutase.
Article in Acta crystallographica. Section F, Structural biology and crystallization communications, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- TheMicrobiology (Reading, England) · 2021Article
- ThermoacidophilicFrontiers in microbiology · 2021Article
- Expression ofMicroorganisms · 2020Article
- Modeling, Mutagenesis andIranian journal of biotechnology · 2020Article
- Characteristics of a Novel Manganese Superoxide Dismutase of a Hadal Sea Cucumber (Marine drugs · 2019Article
- Article
- The first crystal structure of manganese superoxide dismutase from the genus Staphylococcus.Acta crystallographica. Section F, Structural biology communications · 2018Article
- Molecular characterization of a recombinant manganese superoxide dismutase from Lactococcus lactis M4.BioMed research international · 2014Article
- Detection, distribution and characterization of novel superoxide dismutases from Yersinia enterocolitica Biovar 1A.PloS one · 2013Article
- Nonclassical protein secretion by Bacillus subtilis in the stationary phase is not due to cell lysis.Journal of bacteriology · 2011Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sodA gene of Bacillus subtilis was expressed in Escherichia coli, purified and crystallized. The crystal structure of MnSOD was solved by molecular replacement with four dimers per asymmetric unit and refined to an R factor of 21.1% at 1.8 A resolution. The dimer structure is very similar to that of the related enzyme from B. anthracis. Larger structural differences were observed with the human MnSOD, which has one less helix in the helical domain and a longer loop between two beta-strands and also showed differences in three amino acids at the intersubunit interface in the dimer compared with the two bacterial MnSODs. These structural differences can be exploited in the design of drugs that selectively target the Bacillus enzymes.
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