ArticlePlant physiology2008
The Arabidopsis AtOPT3 protein functions in metal homeostasis and movement of iron to developing seeds.
Article in Plant physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
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Who cites it
104 citing papers in PubMed, 256 citations in OpenAlex.
- Toxic metals differentially affect bacterial and fungal seed endophytes in Arabidopsis arenosa.Microbiome · 2026Article
- CITF1 interacts with FIT and regulates copper-iron crosstalk in Arabidopsis.The Plant cell · 2026Article
- Hormonal Status and the Probable Role of Phytohormones in Response of Pea Cultivar Sparkle and Mutant E107 (Plants (Basel, Switzerland) · 2026Article
- Abscisic acid regulates iron accumulation in plant seeds via the PYLs-bHLH IVc-YSLs module.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Age-dependent differential iron deficiency responses of rosette leaves during reproductive stages in Arabidopsis thaliana.Journal of experimental botany · 2025Article
- Copper connections: coordinating transport, sensing and systemic signalling in plants.Quantitative plant biology · 2025Review
- Zinc Enhances Cadmium Accumulation in Shoots of HyperaccumulatorPlants (Basel, Switzerland) · 2024Article
- Transcriptome analysis of iron over-accumulating Arabidopsis genotypes uncover putative novel regulators of systemic and retrograde signaling.The plant genome · 2024Article
- Genetic basis of the historical iron-accumulating dgl and brz mutants in pea.The Plant journal : for cell and molecular biology · 2024Article
- The Small RNA Component ofPlants (Basel, Switzerland) · 2023Article
- Significance and genetic control of membrane transporters to improve phytoremediation and biofortification processes.Molecular biology reports · 2023Review
- Cell type-specific mapping of ion distribution in Arabidopsis thaliana roots.Nature communications · 2023Article
- Loss of OPT3 function decreases phloem copper levels and impairs crosstalk between copper and iron homeostasis and shoot-to-root signaling in Arabidopsis thaliana.The Plant cell · 2023Article
- Biofortification of common bean (Food and energy security · 2023Review
- Iron Induces Resistance Against the Rice Blast Fungus Magnaporthe oryzae Through Potentiation of Immune Responses.Rice (New York, N.Y.) · 2022Article
- POPEYE intercellular localization mediates cell-specific iron deficiency responses.Plant physiology · 2022Article
- The receptor kinase SRF3 coordinates iron-level and flagellin dependent defense and growth responses in plants.Nature communications · 2022Article
- Tea plant roots respond to aluminum-induced mineral nutrient imbalances by transcriptional regulation of multiple cation and anion transporters.BMC plant biology · 2022Article
- Identification of iron and zinc responsive genes in pearl millet using genome-wide RNA-sequencing approach.Frontiers in nutrition · 2022Article
- Endophytic FungusFrontiers in plant science · 2022Article
44 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Arabidopsis thaliana AtOPT3 belongs to the oligopeptide transporter (OPT) family, a relatively poorly characterized family of peptide/modified peptide transporters found in archebacteria, bacteria, fungi, and plants. A null mutation in AtOPT3 resulted in embryo lethality, indicating an essential role for AtOPT3 in embryo development. In this article, we report on the isolation and phenotypic characterization of a second AtOPT3 mutant line, opt3-2, harboring a T-DNA insertion in the 5' untranslated region of AtOPT3. The T-DNA insertion in the AtOPT3 promoter resulted in reduced but sufficient AtOPT3 expression to allow embryo formation in opt3-2 homozygous seeds. Phenotypic analyses of opt3-2 plants revealed three interesting loss-of-function phenotypes associated with iron metabolism. First, reduced AtOPT3 expression in opt3-2 plants resulted in the constitutive expression of root iron deficiency responses regardless of exogenous iron supply. Second, deregulation of root iron uptake processes in opt3-2 roots resulted in the accumulation of very high levels of iron in opt3-2 tissues. Hyperaccumulation of iron in opt3-2 resulted in the formation of brown necrotic areas in opt3-2 leaves and was more pronounced during the seed-filling stage. Third, reduced AtOPT3 expression resulted in decreased accumulation of iron in opt3-2 seeds. The reduced accumulation of iron in opt3-2 seeds is especially noteworthy considering the excessively high levels of accumulated iron in other opt3-2 tissues. AtOPT3, therefore, plays a critical role in two important aspects of iron metabolism, namely, maintenance of whole-plant iron homeostasis and iron nutrition of developing seeds.
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