ArticleDevelopmental biology2008
Direct control of the proneural gene atonal by retinal determination factors during Drosophila eye development.
Article in Developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 44 citations in OpenAlex.
- miR-137 targets Myc to regulate growth during eye development.Development (Cambridge, England) · 2025Article
- Patterning of theFrontiers in cell and developmental biology · 2023Review
- Semper's cells in the insect compound eye: Insights into ocular form and function.Developmental biology · 2021Review
- Hexagonal patterning of the Drosophila eye.Developmental biology · 2021Review
- An E3 ubiquitin ligase, cullin-4 regulates retinal differentiation in Drosophila eye.Genesis (New York, N.Y. : 2000) · 2020Article
- Motif 1 Binding Protein suppresses wingless to promote eye fate in Drosophila.Scientific reports · 2020Article
- Gene regulatory networks during the development of the Drosophila visual system.Current topics in developmental biology · 2020Review
- Article
- The fly eye: Through the looking glass.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Review
- Nuclear receptors connect progenitor transcription factors to cell cycle control.Scientific reports · 2017Article
- Distinct regulation of atonal in a visual organ of Drosophila: Organ-specific enhancer and lack of autoregulation in the larval eye.Developmental biology · 2017Article
- Shared and distinct mechanisms of atonal regulation in Drosophila ocelli and compound eyes.Developmental biology · 2016Article
- ESCRT-0 complex modulates Rbf-mutant cell survival by regulating Rhomboid endosomal trafficking and EGFR signaling.Journal of cell science · 2016Article
- ato-Gal4 fly lines for gene function analysis: Eya is required in late progenitors for eye morphogenesis.Genesis (New York, N.Y. : 2000) · 2015Article
- The Hippo pathway effector Yki downregulates Wg signaling to promote retinal differentiation in the Drosophila eye.Development (Cambridge, England) · 2015Article
- Eye selector logic for a coordinated cell cycle exit.PLoS genetics · 2015Article
- The homeodomain of Eyeless regulates cell growth and antagonizes the paired domain-dependent retinal differentiation function.Protein & cell · 2015Article
- Daughterless homodimer synergizes with Eyeless to induce Atonal expression and retinal neuron differentiation.Developmental biology · 2014Article
- Onset of atonal expression in Drosophila retinal progenitors involves redundant and synergistic contributions of Ey/Pax6 and So binding sites within two distant enhancers.Developmental biology · 2014Article
- Dynamic rewiring of the Drosophila retinal determination network switches its function from selector to differentiation.PLoS genetics · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The determination of neuronal identity in Drosophila cells depends on the accurate expression of proneural genes. The proneural gene atonal (ato) encodes a basic-HLH protein required for photoreceptor and chordotonal organ formation. The initial expression of ato in imaginal discs is regulated by sequences that lie 3' to its open reading frame. In this report, we show that the initial ato transcription in different imaginal discs is regulated by distinct 3' cis-regulatory sequences. The eye-specific ato 3' cis-regulatory sequence consists of two distinct elements we term 2.8 PB and 3.6 BP that regulate ato transcription during different stages of eye development. The 2.8 PB enhancer contains a highly conserved consensus binding site for the retinal determination (RD) factor Sine oculis (So). Mutation of this So binding site abolishes 2.8 PB enhancer activity. Furthermore the RD factors So and Eyes absent (Eya) are required for 2.8 PB enhancer activity and can induce ectopic 2.8 PB reporter expression. In contrast, ectopic Dpp signaling is not sufficient to induce ato 3' enhancer activation but can induce increased levels of RD factor Dachshund (Dac) and synergize with So and Eya to increase ato 3' enhancer activity. These results demonstrate a direct mechanism by which the RD factors regulate ato expression and suggest an important role of Dpp in the activation of ato 3' enhancer is to regulate the levels of RD factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.