ArticleMolecular and biochemical parasitology2008
The canine hookworm genome: analysis and classification of Ancylostoma caninum survey sequences.
Article in Molecular and biochemical parasitology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Pharmacological Profiling of a Brugia malayi Muscarinic Acetylcholine Receptor as a Putative Antiparasitic Target.Antimicrobial agents and chemotherapy · 2023Article
- Of dogs and hookworms: man's best friend and his parasites as a model for translational biomedical research.Parasites & vectors · 2018Review
- The hookworm Ancylostoma ceylanicum intestinal transcriptome provides a platform for selecting drug and vaccine candidates.Parasites & vectors · 2016Article
- Pan-phylum Comparison of Nematode Metabolic Potential.PLoS neglected tropical diseases · 2015Article
- The genome and transcriptome of the zoonotic hookworm Ancylostoma ceylanicum identify infection-specific gene families.Nature genetics · 2015Article
- Two potential hookworm DAF-16 target genes, SNR-3 and LPP-1: gene structure, expression profile, and implications of a cis-regulatory element in the regulation of gene expression.Parasites & vectors · 2015Article
- A nuclear single-nucleotide polymorphism (SNP) potentially useful for the separation of Rhodnius prolixus from members of the Rhodnius robustus cryptic species complex (Hemiptera: Reduviidae).Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2013Article
- Molecular identification of Ancylostoma caninum isolated from cats in southern China based on complete ITS sequence.BioMed research international · 2013Article
- Genome cartography: charting the apicomplexan genome.Trends in parasitology · 2011Review
- Article
- Genome-wide analysis reveals novel genes essential for heme homeostasis in Caenorhabditis elegans.PLoS genetics · 2010Article
- Characterizing Ancylostoma caninum transcriptome and exploring nematode parasitic adaptation.BMC genomics · 2010Article
- Massively parallel sequencing and analysis of the Necator americanus transcriptome.PLoS neglected tropical diseases · 2010Article
- Helminth genomics: The implications for human health.PLoS neglected tropical diseases · 2009Review
- The putative cyclooctadepsipeptide receptor depsiphilin of the canine hookworm Ancylostoma caninum.Parasitology research · 2009Article
- Systematic analysis of insertions and deletions specific to nematode proteins and their proposed functional and evolutionary relevance.BMC evolutionary biology · 2009Article
- Nematode.net update 2008: improvements enabling more efficient data mining and comparative nematode genomics.Nucleic acids research · 2009Article
- NemaPath: online exploration of KEGG-based metabolic pathways for nematodes.BMC genomics · 2008Article
- Comparative transcriptomic analysis of two important life stages of Angiostrongylus cantonensis: fifth-stage larvae and female adults.Genetics and molecular biologyArticle
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Hookworms infect nearly a billion people. The Ancylostoma caninum hookworm of canids is a model for studying human infections and information from its genome coupled with functional genomics and proteomics can accelerate progress towards hookworm control. As a step towards a full-scale A. caninum genome project, we generated 104,000 genome survey sequences (GSSs) and determined the genome size of the canine hookworm. GSSs assembled into 57.6 Mb of unique sequence from a genome that we estimate by flow cytometry of isolated nuclei to be 347 +/- 1.2 Mb, substantially larger than other Rhabditina species. Gene finding identified 5538 genes in the GSS assembly, for a total of 9113 non-redundant A. caninum genes when EST sequences are also considered. Functional classifications of many of the 70% of genes with homology to genes in other species are provided based on gene ontology and KEGG associations and secreted and membrane-bound proteins are also identified.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.