ArticleCellular immunology2007
Retinoic acid promotes mouse splenic B cell surface IgG expression and maturation stimulated by CD40 and IL-4.
Article in Cellular immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Review
- An overview on role of nutrition on COVID-19 immunity: Accumulative review from available studies.Clinical nutrition open science · 2023Review
- Loss of RARRES1 function Promotes Follicular Lymphomagenesis and Inhibits B cell Differentiation in Mice.International journal of biological sciences · 2022Article
- Mega doses of retinol: A possible immunomodulation in Covid-19 illness in resource-limited settings.Reviews in medical virology · 2021Review
- Vitamin A Plasma Levels in COVID-19 Patients: A Prospective Multicenter Study and Hypothesis.Nutrients · 2021Observational
- Innate Mechanisms in Selective IgA Deficiency.Frontiers in immunology · 2021Review
- Microbiota Metabolite Short-Chain Fatty Acids Facilitate Mucosal Adjuvant Activity of Cholera Toxin through GPR43.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Control of Innate and Adaptive Lymphocytes by the RAR-Retinoic Acid Axis.Immune network · 2018Review
- Ascorbic acid synthesis and transportation capacity in old laying hens and the effects of dietary supplementation with ascorbic acid.Journal of animal science and biotechnology · 2018Article
- Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases.Mediators of inflammation · 2018Review
- All- Trans-Retinoic Acid Augments the Histopathological Outcome of Neuroinflammation and Neurodegeneration in Lupus-Prone MRL/lpr Mice.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2017Article
- Could retinoids be a potential treatment for rheumatic diseases?Rheumatology international · 2015Review
- Paradoxical effects of all-trans-retinoic acid on lupus-like disease in the MRL/lpr mouse model.PloS one · 2015Article
- Aldehyde dehydrogenase-1a1 induces oncogene suppressor genes in B cell populations.Biochimica et biophysica acta · 2013Article
- Critical role for all-trans retinoic acid for optimal effector and effector memory CD8 T cell differentiation.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Vitamin A and retinoic acid in T cell-related immunity.The American journal of clinical nutrition · 2012Review
- Oral vitamin A and retinoic acid supplementation stimulates antibody production and splenic Stra6 expression in tetanus toxoid-immunized mice.The Journal of nutrition · 2012Article
- Retinoic acid signalling in gastrointestinal parasite infections: lessons from mouse models.Parasite immunology · 2012Review
- Retinoic acid and α-galactosylceramide differentially regulate B cell activation in vitro and augment antibody production in vivo.Clinical and vaccine immunology : CVI · 2011Article
- Research resource: Comparative nuclear receptor atlas: basal and activated peritoneal B-1 and B-2 cells.Molecular endocrinology (Baltimore, Md.) · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Retinoic acid (RA) increases antibody production in vivo but its role in B-cell activation is unclear. In a model of purified mouse splenic B cells stimulated by CD40 coreceptor (as a surrogate of T cell co-stimulation), IL-4, a principal Th-2 cytokine, and ligation of the B-cell antigen receptor, CD40 engagement or IL-4 alone induced B-cell activation indicated by increased Ig gamma1 germline transcripts, cell proliferation, and surface (s)IgG1 expression, while triple stimulation with the combination of anti-CD40/IL-4/anti-mu synergized to heighten B-cell activation. Although RA was growth inhibitory for anti-CD40-activated B cells, RA increased the proportion of B cells that had more differentiated phenotypes, such as expression of higher level of activation-induced deaminase, Blimp-1, CD138/syndecan-1 and sIgG1. Overall, RA can promote B-cell maturation at the population level by increasing the number of sIgG1 and CD138 expressing cells, which may be related to the potentiation of humoral immunity in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.