ArticleVaccine2008
Infection of monocytes or immature dendritic cells (DCs) with an attenuated rabies virus results in DC maturation and a strong activation of the NFkappaB signaling pathway.
Article in Vaccine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- A comparative analysis of the dendritic cell response upon exposure to different rabies virus strains.PLoS neglected tropical diseases · 2025Article
- Neuroglia infection by rabies virus after anterograde virus spread in peripheral neurons.Acta neuropathologica communications · 2020Article
- Responsiveness of various reservoir species to oral rabies vaccination correlates with differences in vaccine uptake of mucosa associated lymphoid tissues.Scientific reports · 2020Article
- Phosphoprotein Gene of Wild-Type Rabies Virus Plays a Role in Limiting Viral Pathogenicity and Lowering the Enhancement of BBB Permeability.Frontiers in microbiology · 2020Article
- Environmental distribution of certain modified live-virus vaccines with a high safety profile presents a low-risk, high-reward to control zoonotic diseases.Scientific reports · 2019Article
- Article
- Protection Against CNS-Targeted Rabies Virus Infection is Dependent upon Type-1 Immune Mechanisms Induced by Live-Attenuated Rabies Vaccines.Tropical medicine and infectious disease · 2017Article
- Development of in vitro and in vivo rabies virus neutralization assays based on a high-titer pseudovirus system.Scientific reports · 2017Article
- Monocytes and B cells support active replication of Chandipura virus.BMC infectious diseases · 2016Article
- Subversion of the Immune Response by Rabies Virus.Viruses · 2016Review
- Generation of a More Immunogenic Measles Vaccine by Increasing Its Hemagglutinin Expression.Journal of virology · 2016Article
- Profile of Cytokines and Chemokines Triggered by Wild-Type Strains of Rabies Virus in Mice.The American journal of tropical medicine and hygiene · 2016Article
- The inability of wild-type rabies virus to activate dendritic cells is dependent on the glycoprotein and correlates with its low level of the de novo-synthesized leader RNA.Journal of virology · 2015Article
- Pre- and post-exposure safety and efficacy of attenuated rabies virus vaccines are enhanced by their expression of IFNγ.Virology · 2015Article
- B cell infection and activation by rabies virus-based vaccines.Journal of virology · 2013Article
- Rabies virus is recognized by the NLRP3 inflammasome and activates interleukin-1β release in murine dendritic cells.Journal of virology · 2013Article
- Intramuscular inoculation of mice with the live-attenuated recombinant rabies virus TriGAS results in a transient infection of the draining lymph nodes and a robust, long-lasting protective immune response against rabies.Journal of virology · 2013Article
- Passive carriage of rabies virus by dendritic cells.SpringerPlus · 2013Article
- Rabies virus expressing dendritic cell-activating molecules enhances the innate and adaptive immune response to vaccination.Journal of virology · 2011Article
- Rabies virus as a research tool and viral vaccine vector.Advances in virus research · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
To assess the potential role of dendritic cells (DCs) or monocytes in the development of a protective immune response, we infected human immature DCs or monocytes with a live rabies virus (RV) vaccine strain (SPBNGAS-GAS) and a pathogenic RV (DOG4). Both cell types were infected with SPBNGAS-GAS and DOG4 and both RVs were similarly potent in inducing maturation of immature DCs or monocytes. However, in contrast to DOG4, SPBNGAS-GAS induced very high levels of IFN-alpha1 mRNA in monocytes and DCs. Furthermore, at least 26 other genes related to the NFkappaB signaling pathway were strongly upregulated in SPBNGAS-GAS-infected DCs, but only somewhat increased in DOG4-infected cells. Thus, the extent of upregulation of NFkappaB pathway-related genes in DCs infected with the live RV vaccine strain might explain the strong protective activity of SPBNGAS-GAS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.