ArticleThe Journal of urology2008
Bacterial cystitis is accompanied by increased peripheral thermal sensitivity in mice.
Article in The Journal of urology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Bioinformatics Analysis of the Anti-Inflammatory Mechanism and Potential Therapeutic Efficacy ofInternational journal of molecular sciences · 2025Article
- Insulin receptor signaling engages bladder urothelial defenses that limit urinary tract infection.Cell reports · 2024Article
- Establishment of new transurethral catheterization methods for male mice.Biology methods & protocols · 2024Article
- The emergence of animal models of chronic pain and logistical and methodological issues concerning their use.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Transurethral Instillation Procedure in Adult Male Mouse.Journal of visualized experiments : JoVE · 2017Article
- An overview of animal models of pain: disease models and outcome measures.The journal of pain · 2013Review
- VEGF induces sensory and motor peripheral plasticity, alters bladder function, and promotes visceral sensitivity.BMC physiology · 2012Article
- O-antigen modulates infection-induced pain states.PloS one · 2012Article
- Models of inflammation of the lower urinary tract.Neurourology and urodynamics · 2011Review
- Host-pathogen interactions mediating pain of urinary tract infection.The Journal of infectious diseases · 2010Article
- Mycobacteria attenuate nociceptive responses by formyl peptide receptor triggered opioid peptide release from neutrophils.PLoS pathogens · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeVisceral inflammation and pain associated with chemical cystitis produce increased sensitivity to noxious stimuli in the sacral dermatomes. We determined whether a similar sensitization occurs in response to bacterial cystitis. MATERIALS AND
methodsBacterial cystitis was induced by intravesical instillation of Escherichia coli 1677 in female C57BL/6N and C3H/OuJ mice (Jackson Laboratories, Bar Harbor, Maine). C3H/HeJ mice (Jackson Laboratories) served as a control because C3H/HeJ mice lack functional toll-like receptor 4, which is an essential component of cellular recognition of bacterial lipopolysaccharide. Hind paw sensitivity to thermal stimulus was quantitatively determined 1, 2, 7 and 14 days after infection.
resultsIntravesical instillation of E. coli produced infection in all strains of mice. Infection persisted in all C3H/OuJ and C3H/HeJ mice but it spontaneously cleared in some C57BL/6N mice. Increased sensitivity to thermal stimuli was observed in C57BL/6N and C3H/OuJ mice starting 1 to 2 days after E. coli instillation and it was still present 14 days after instillation. Increased sensitivity to thermal stimuli did not occur in C3H/HeJ mice.
conclusionsE. coli induced cystitis produced increased sensitivity to peripheral thermal stimuli in mice with competent toll-like receptor 4.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.