ArticleEpidemiology and infection2008
Lack of response of INT-407 cells to the presence of non-culturable Campylobacter jejuni.
Article in Epidemiology and infection, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Campylobacter jejuni Triggers Signaling through Host Cell Focal Adhesions To Inhibit Cell Motility.mBio · 2021Article
- Role of putative virulence traits of Campylobacter jejuni in regulating differential host immune responses.Journal of microbiology (Seoul, Korea) · 2019Article
- Surfactant protein-D attenuates the lipopolysaccharide-induced inflammation in human intestinal cells overexpressing toll-like receptor 4.Pediatric surgery international · 2016Article
- Cronobacter sakazakii: stress survival and virulence potential in an opportunistic foodborne pathogen.Gut microbes · 2014Review
- Putative mechanisms and biological role of coccoid form formation in Campylobacter jejuni.European journal of microbiology & immunology · 2012Review
- Finnish Campylobacter jejuni strains of multilocus sequence type ST-22 complex have two lineages with different characteristics.PloS one · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many contradictory articles on the infectivity of non-culturable Campylobacter jejuni can be found. We studied the effect of non-culturable C. jejuni in an in vitro assay. To prevent the potential effect of a few culturable bacteria in the non-culturable suspension, INT-407 cells, which mimic the outer cell layer in the small intestines, were exposed to culturable C. jejuni suspensions with or without non-culturable C. jejuni. The number of bacteria adhering to and/or invading INT-407 cells and the IL-8 secretion were measured. No differences were found between bacterial suspensions with or without non-culturable C. jejuni added. These findings show that non-culturable C. jejuni do not adhere to or invade INT-407 cells and do not induce an immune response. As previous studies showed a correlation between the used in vitro assays and the effect in vivo, our study strongly suggests that culturability is a good indicator of the risk for C. jejuni infection.
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Registered trials
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