Evidence map›Paper›PMID 18081009›Full record

ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2008

Drosophila telomeres: an exception providing new insights.

James M Mason, Radmila Capkova Frydrychova, Harald Biessmann

Abstract readReview
In one paragraph

Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Ageing effects of social environments in 'non-social' insects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Acytota and the evolution of complexity.European biophysics journal : EBJ · 2025
    Review
  7. Review
  8. Article
  9. Article
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  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Lysine-36 ofbioRxiv : the preprint server for biology · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Article

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

James M MasonLaboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Radmila Capkova Frydrychova
Harald Biessmann

Funding

TELOMERE STRUCTURE IN DROSOPHILAZ01ES021054 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI MASON, JAMES M · 1994 to 2008
$2.2M
TELOMERE CHROMATIN STRUCTURER01GM056729 · NIGMS · UNIVERSITY OF CALIFORNIA IRVINE · PI BIESSMANN, HARALD · 1999 to 2002
$831k
Chromatin Structure in Drosophila TelomeresZ01ES101764 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI MASON, JAMES M · 2004 to 2008
$163k
Intramural NIH HHS Z01 ES101764NIGMS NIH HHS GM-56729NIGMS NIH HHS R01 GM056729
6 · The paper itself

Abstract

Drosophila telomeres comprise DNA sequences that differ dramatically from those of other eukaryotes. Telomere functions, however, are similar to those found in telomerase-based telomeres, even though the underlying mechanisms may differ. Drosophila telomeres use arrays of retrotransposons to maintain chromosome length, while nearly all other eukaryotes rely on telomerase-generated short repeats. Regardless of the DNA sequence, several end-binding proteins are evolutionarily conserved. Away from the end, the Drosophila telomeric and subtelomeric DNA sequences are complexed with unique combinations of proteins that also modulate chromatin structure elsewhere in the genome. Maintaining and regulating the transcriptional activity of the telomeric retrotransposons in Drosophila requires specific chromatin structures and, while telomeric silencing spreads from the terminal repeats in yeast, the source of telomeric silencing in Drosophila is the subterminal arrays. However, the subterminal arrays in both species may be involved in telomere-telomere associations and/or communication.

Indexed as

AnimalsChromosomesDNA-Binding ProteinsDrosophilaEvolution, MolecularGene SilencingModels, BiologicalMutagenesis, InsertionalOligonucleotide Array Sequence AnalysisPolycomb-Group ProteinsRepetitive Sequences, Nucleic AcidRepressor ProteinsRetroelementsTelomereDNA-Binding ProteinsPolycomb-Group ProteinsRepressor ProteinsRetroelements

Identifiers

PMID18081009
PMCPMC2804870

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.